Process of inflammation and complex interactions between immune and cancer cells within
tumor microenvironment are known to drive and shape the outcome of the neoplastic …

Mechanotransduction, the translation of mechanical stimuli into biological signals, is a
crucial mechanism involved in the function of fundamentally all cell types. In many solid …

The membrane of cells and intracellular organelles is 2 composed of two layers of lipids,
preventing the free “in 3 and out” movement of water and solutes that are necessary 4 for …

Cellular senescence is implicated in a great number of diseases including cancer. Although
alterations in mitochondrial metabolism were reported as senescence drivers, the …

Colorectal cancer is a multifaceted disease which is therapeutically challenging. Based on
insights gleaned from almost a quarter century of research, it is obvious that deregulation of …

Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

The calcium-activated chloride channel TMEM16A is intimately linked to cancers. Over
decades, TMEM16A over-expression and contribution to prognosis have been widely …

Potassium (K+) channels are highly regulated membrane proteins that control the potassium
ion flux and respond to different cellular stimuli. These ion channels are grouped into three …

A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

Ions are the cornerstones of various biological functions and have been widely used for
tumor therapy, called ion interference therapy (IIT). Calcium ion (Ca 2+) is one of the most …