As early and effective antiretroviral therapy has become more widespread, HIV has
transitioned from a progressive, fatal disease to a chronic, manageable disease marked by …

Antiretroviral therapy has largely transformed HIV infection into a chronic disease condition.
As such, physicians and other providers caring for individuals living with HIV infection need …

Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …

Background Integrase strand transfer inhibitors (INSTIs) are recommended components of
initial antiretroviral therapy with two nucleoside reverse transcriptase inhibitors. Bictegravir is …

Importance Approximately 1.1 million persons in the United States are currently living with
HIV, and more than 700 000 persons have died of AIDS since the first cases were reported …

Background Bictegravir, co-formulated with emtricitabine and tenofovir alafenamide, has
shown good efficacy and tolerability, and similar bone, renal, and lipid profiles to …

Background The single-tablet regimen consisting of bictegravir, emtricitabine, and tenofovir
alafenamide is recommended for treatment of HIV-1 infection on the basis of data from 48 …

Human immunodeficiency virus (HIV) is a chronic infectious disease currently requiring
lifelong antiretroviral therapy (ART). People living with HIV (PLWH) face an increased risk of …

Neutrophils are important components of the innate immune system that mediate pathogen
defense by multiple processes including phagocytosis, release of proteolytic enzymes …

Importance The vascular risk attributable to HIV infection is rising. The heterogeneity of the
samples studied is an obstacle to understanding whether HIV is a vascular risk across …