The T-cell response to HIV
B Walker, A McMichael - Cold Spring …, 2012 - perspectivesinmedicine.cshlp.org
HIV is a disease in which the original clinical observations of severe opportunistic infections
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …
gave the first clues regarding the underlying pathology, namely that HIV is essentially an …
Immunology and the elusive AIDS vaccine
Develo** a human immunodeficiency virus (HIV) vaccine is critical to end the global
acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this …
acquired immunodeficiency syndrome (AIDS) epidemic, but many question whether this …
The replication-competent HIV-1 latent reservoir is primarily established near the time of therapy initiation
MR Abrahams, SB Joseph, N Garrett, L Tyers… - Science translational …, 2019 - science.org
Although antiretroviral therapy (ART) is highly effective at suppressing HIV-1 replication, the
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …
virus persists as a latent reservoir in resting CD4+ T cells during therapy. This reservoir …
Whole genome deep sequencing of HIV-1 reveals the impact of early minor variants upon immune recognition during acute infection
MR Henn, CL Boutwell, P Charlebois… - PLoS …, 2012 - journals.plos.org
Deep sequencing technologies have the potential to transform the study of highly variable
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …
viral pathogens by providing a rapid and cost-effective approach to sensitively characterize …
[HTML][HTML] Translating HIV sequences into quantitative fitness landscapes predicts viral vulnerabilities for rational immunogen design
A prophylactic or therapeutic vaccine offers the best hope to curb the HIV-AIDS epidemic
grip** sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral …
grip** sub-Saharan Africa, but it remains elusive. A major challenge is the extreme viral …
Genetic impact of vaccination on breakthrough HIV-1 sequences from the STEP trial
M Rolland, S Tovanabutra, AC Decamp, N Frahm… - Nature medicine, 2011 - nature.com
We analyzed HIV-1 genome sequences from 68 newly infected volunteers in the STEP HIV-
1 vaccine trial. To determine whether the vaccine exerted selective T cell pressure on …
1 vaccine trial. To determine whether the vaccine exerted selective T cell pressure on …
The Fitness Landscape of HIV-1 Gag: Advanced Modeling Approaches and Validation of Model Predictions by In Vitro Testing
Viral immune evasion by sequence variation is a major hindrance to HIV-1 vaccine design.
To address this challenge, our group has developed a computational model, rooted in …
To address this challenge, our group has developed a computational model, rooted in …
Coordinate linkage of HIV evolution reveals regions of immunological vulnerability
Cellular immune control of HIV is mediated, in part, by induction of single amino acid
mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we …
mutations that reduce viral fitness, but compensatory mutations limit this effect. Here, we …
Impact of pre-adapted HIV transmission
Human leukocyte antigen class I (HLA)-restricted CD8+ T lymphocyte (CTL) responses are
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
crucial to HIV-1 control. Although HIV can evade these responses, the longer-term impact of …
Widespread impact of HLA restriction on immune control and escape pathways of HIV-1
The promiscuous presentation of epitopes by similar HLA class I alleles holds promise for a
universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes …
universal T-cell-based HIV-1 vaccine. However, in some instances, cytotoxic T lymphocytes …