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The cell biology of ferroptosis
Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms …
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
Q Zhou, Y Meng, D Li, L Yao, J Le, Y Liu… - Signal transduction and …, 2024 - nature.com
Ferroptosis is a non-apoptotic form of regulated cell death characterized by the lethal
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …
accumulation of iron-dependent membrane-localized lipid peroxides. It acts as an innate …
Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones
Ferroptosis, a cell death process driven by iron-dependent phospholipid peroxidation, has
been implicated in various diseases. There are two major surveillance mechanisms to …
been implicated in various diseases. There are two major surveillance mechanisms to …
Regulation of ferroptosis by lipid metabolism
Ferroptosis is an iron-dependent lethal mechanism that can be activated in disease and is a
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …
proposed target for cancer therapy. Ferroptosis is defined by the overwhelming …
Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research
X Tong, R Tang, M **ao, J Xu, W Wang… - Journal of hematology & …, 2022 - Springer
Many types of human cells self-destruct to maintain biological homeostasis and defend the
body against pathogenic substances. This process, called regulated cell death (RCD), is …
body against pathogenic substances. This process, called regulated cell death (RCD), is …
CD8+ T cells in the cancer-immunity cycle
CD8+ T cells are end effectors of cancer immunity. Most forms of effective cancer
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
immunotherapy involve CD8+ T cell effector function. Here, we review the current …
Ferroptosis of tumour neutrophils causes immune suppression in cancer
Ferroptosis is a non-apoptotic form of regulated cell death that is triggered by the
discoordination of regulatory redox mechanisms culminating in massive peroxidation of …
discoordination of regulatory redox mechanisms culminating in massive peroxidation of …
[HTML][HTML] Ferroptosis turns 10: Emerging mechanisms, physiological functions, and therapeutic applications
Ferroptosis, a form of cell death driven by iron-dependent lipid peroxidation, was identified
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
as a distinct phenomenon and named a decade ago. Ferroptosis has been implicated in a …
Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
HR **, J Wang, ZJ Wang, MJ **, BH **a… - Journal of hematology & …, 2023 - Springer
Lipid metabolic reprogramming is an emerging hallmark of cancer. In order to sustain
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …
uncontrolled proliferation and survive in unfavorable environments that lack oxygen and …
The role of lipids in cancer progression and metastasis
Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …
as a signaling molecule, and being a structural component of membranes); however, an …