Diabetes prevalence continues to climb with the aging population. Type 2 diabetes (T2D),
which constitutes most cases, is metabolically acquired. Diabetic peripheral neuropathy …

Central neuropathic pain arises from a lesion or disease of the central somatosensory
nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related …

Neuropathic pain remains a significant unmet medical need. Several recommendations
have recently been proposed concerning pharmacotherapy, neurostimulation techniques …

Peripheral neuropathy is one of the most common complications of both type 1 and type 2
diabetes. Up to half of patients with diabetes develop neuropathy during the course of their …

Over the past few decades, substantial advances have been made in neuropathic pain
clinical research. An updated definition and classification have been agreed. Validated …

Abstract Treatment of neuropathic pain remains inadequate despite the elucidation of
multiple pathophysiological mechanisms and the development of promising therapeutic …

Chronic pain remains challenging to both diagnose and treat. These challenges, in part,
arise from limited systems-level understanding of the basic mechanisms that process …

Over the past decade, the mechanisms underlying placebo effects have begun to be
identified. At the same time, the placebo response appears to have increased in …

Neuropathic pain management should not be restricted to pharmacotherapy but now
encompasses multiple approaches including particularly neuromodulation techniques …

Osteoarthritis (OA) is the most common form of arthritis worldwide, affecting~ 500 million
people, yet there are no effective treatments to halt its progression. Without any structure …