Ultra-processed foods and food additives in gut health and disease

K Whelan, AS Bancil, JO Lindsay… - Nature Reviews …, 2024 - nature.com
Ultra-processed foods (UPFs) and food additives have become ubiquitous components of
the modern human diet. There is increasing evidence of an association between diets rich in …

Multimodal interactions of drugs, natural compounds and pollutants with the gut microbiota

AE Lindell, M Zimmermann-Kogadeeva… - Nature Reviews …, 2022 - nature.com
The gut microbiota contributes to diverse aspects of host physiology, ranging from
immunomodulation to drug metabolism. Changes in the gut microbiota composition are …

Replacement of refined sugar by natural sweeteners: focus on potential health benefits

S Arshad, T Rehman, S Saif, MSR Rajoka… - Heliyon, 2022 - cell.com
Refined sugar is a processed product containing 99% sucrose, which is obtained from
sugarcane (70%) or sugar beet (30%). In modern societies, sugar continues to play a …

Artificial sweeteners: history and new concepts on inflammation

AR Basson, A Rodriguez-Palacios, F Cominelli - Frontiers in nutrition, 2021 - frontiersin.org
Since the introduction of artificial sweeteners (AS) to the North American market in the
1950s, a growing number of epidemiological and animal studies have suggested that AS …

Potential effects of sucralose and saccharin on gut microbiota: a review

S Del Pozo, S Gómez-Martínez, LE Díaz, E Nova… - Nutrients, 2022 - mdpi.com
Artificial sweeteners are additives widely used in our diet. Although there is no consensus,
current evidence indicates that sucralose and saccharin could influence the gut microbiota …

Complexification of in vitro models of intestinal barriers, a true challenge for a more accurate alternative approach

MJ Haddad, W Sztupecki, C Delayre-Orthez… - International journal of …, 2023 - mdpi.com
The use of cell models is common to mimic cellular and molecular events in interaction with
their environment. In the case of the gut, the existing models are of particular interest to …

Toxicological and pharmacokinetic properties of sucralose-6-acetate and its parent sucralose: in vitro screening assays

SS Schiffman, EH Scholl, TS Furey… - Journal of Toxicology …, 2023 - Taylor & Francis
The purpose of this study was to determine the toxicological and pharmacokinetic properties
of sucralose-6-acetate, a structural analog of the artificial sweetener sucralose. Sucralose-6 …

Non-nutritive sweeteners and their impacts on the gut microbiome and host physiology

IL Richardson, SA Frese - Frontiers in Nutrition, 2022 - frontiersin.org
Non-nutritive sweeteners (NNS) are broadly incorporated into foods, especially those
representing a growing share of the beverage market. NNS are viewed as a noncaloric and …

Dissecting ultra-processed foods and drinks: Do they have a potential to impact the brain?

O Contreras-Rodriguez, M Solanas… - Reviews in Endocrine …, 2022 - Springer
Ultra-processed foods and drinks (UPF) are formulation of ingredients, mostly of exclusive
industrial use, that result from a series of industrial processes. They usually have a low …

The artificial sweetener neotame negatively regulates the intestinal epithelium directly through T1R3-signaling and indirectly through pathogenic changes to model …

A Shil, LM Ladeira Faria, CA Walker… - Frontiers in Nutrition, 2024 - frontiersin.org
Introduction Recent studies have indicated considerable health risks associated with the
consumption of artificial sweeteners. Neotame is a relatively new sweetener in the global …