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Single-cell trajectory analysis reveals a CD9 positive state to contribute to exit from stem cell-like and embryonic diapause states and transit to drug-resistant states
Bromo-and extra-terminal domain (BET) inhibitors (BETi) have been shown to decrease
tumor growth in preclinical models and clinical trials. However, toxicity and rapid emergence …
tumor growth in preclinical models and clinical trials. However, toxicity and rapid emergence …
Single-cell chromatin accessibility profiling of acute myeloid leukemia reveals heterogeneous lineage composition upon therapy-resistance
Acute myeloid leukemia (AML) is a heterogeneous disease characterized by high rate of
therapy resistance. Since the cell of origin can impact response to therapy, it is crucial to …
therapy resistance. Since the cell of origin can impact response to therapy, it is crucial to …
A unified model-based framework for doublet or multiplet detection in single-cell multiomics data
Droplet-based single-cell sequencing techniques rely on the fundamental assumption that
each droplet encapsulates a single cell, enabling individual cell omics profiling. However …
each droplet encapsulates a single cell, enabling individual cell omics profiling. However …
Single-cell epigenome analysis identifies molecular events controlling direct conversion of human fibroblasts to pancreatic ductal-like cells
Cell fate can be reprogrammed by ectopic expression of lineage-specific transcription
factors (TFs). However, the exact cell state transitions during transdifferentiation are still …
factors (TFs). However, the exact cell state transitions during transdifferentiation are still …
Approaches of single-cell analysis in crop improvement
U Srivastava, S Singh - Genomics of Cereal Crops, 2022 - Springer
Single-cell multiomics approaches have the potential to maximize the scientific impact on
crop improvement. These technologies have become increasingly possible to perform …
crop improvement. These technologies have become increasingly possible to perform …
Multimodal analysis reveals genes driving neuronal maturation in the primate prefrontal cortex
The dorsolateral prefrontal cortex (dlPFC) is an evolutionarily derived cortical region in
primates critical for high-level cognitive functions and implicated in various neuropsychiatric …
primates critical for high-level cognitive functions and implicated in various neuropsychiatric …
[HTML][HTML] Protocol to identify defined reprogramming factor expression using a factor-indexing single-nuclei multiome sequencing approach
Ectopic expression of lineage-specific transcription factors (TFs) of another cell type can
induce cell fate reprogramming. However, the heterogeneity of reprogramming cells has …
induce cell fate reprogramming. However, the heterogeneity of reprogramming cells has …
Multiomics map** and characterization of cellular senescence in aging human skeletal muscle uncovers a novel senotherapeutic for sarcopenia
Y Li, C Li, Q Zhou, X Liu, Y Qiao, T ** and characterization of cellular senescence in aging human muscle uncovers novel senotherapeutics for sarcopenia
Cellular senescence is recognized as a hallmark of organismal aging but how it drives aging
particularly in human tissues is not fully understood, partly due to the complex …
particularly in human tissues is not fully understood, partly due to the complex …