Gut–skin axis: current knowledge of the interrelationship between microbial dysbiosis and skin conditions

B De Pessemier, L Grine, M Debaere, A Maes… - Microorganisms, 2021 - mdpi.com
The microbiome plays an important role in a wide variety of skin disorders. Not only is the
skin microbiome altered, but also surprisingly many skin diseases are accompanied by an …

Antimicrobial host defence peptides: functions and clinical potential

N Mookherjee, MA Anderson, HP Haagsman… - Nature reviews Drug …, 2020 - nature.com
Cationic host defence peptides (CHDP), also known as antimicrobial peptides, are naturally
occurring peptides that can combat infections through their direct microbicidal properties …

Nanomaterials and nanomaterials-based drug delivery to promote cutaneous wound healing

T Liu, Y Lu, R Zhan, W Qian, G Luo - Advanced Drug Delivery Reviews, 2023 - Elsevier
Various factors could damage the structure and integrity of skin to cause wounds.
Nonhealing or chronic wounds seriously affect the well-being of patients and bring heavy …

Group A Streptococcus induces GSDMA-dependent pyroptosis in keratinocytes

DL LaRock, AF Johnson, S Wilde, JS Sands… - Nature, 2022 - nature.com
Gasdermins (GSDMs) are a family of pore-forming effectors that permeabilize the cell
membrane during the cell death program pyroptosis. GSDMs are activated by proteolytic …

Constitutive immune mechanisms: mediators of host defence and immune regulation

SR Paludan, T Pradeu, SL Masters… - Nature Reviews …, 2021 - nature.com
The immune system enables organisms to combat infections and to eliminate endogenous
challenges. Immune responses can be evoked through diverse inducible pathways …

Cystic fibrosis and Pseudomonas aeruginosa: the host-microbe interface

S Malhotra, D Hayes Jr, DJ Wozniak - Clinical microbiology …, 2019 - Am Soc Microbiol
In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Antimicrobials from human skin commensal bacteria protect against Staphylococcus aureus and are deficient in atopic dermatitis

T Nakatsuji, TH Chen, S Narala, KA Chun… - Science translational …, 2017 - science.org
The microbiome can promote or disrupt human health by influencing both adaptive and
innate immune functions. We tested whether bacteria that normally reside on human skin …

[HTML][HTML] Antimicrobial peptides: an emerging category of therapeutic agents

M Mahlapuu, J Håkansson, L Ringstad… - Frontiers in cellular and …, 2016 - frontiersin.org
Antimicrobial peptides (AMPs), also known as host defense peptides, are short and
generally positively charged peptides found in a wide variety of life forms from …

Bacterial resistance to antibacterial agents: Mechanisms, control strategies, and implications for global health

T Li, Z Wang, J Guo, C de la Fuente-Nunez… - Science of The Total …, 2023 - Elsevier
The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

The coppery age: copper (Cu)‐involved nanotheranostics

C Dong, W Feng, W Xu, L Yu, H **ang… - Advanced …, 2020 - Wiley Online Library
As an essential trace element in the human body, transitional metal copper (Cu) ions are the
bioactive components within the body featuring dedicated biological effects such as …