Ultrasound and x-ray imageable poloxamer-based hydrogel for loco-regional therapy delivery in the liver

JF Delgado, JW Owen, WF Pritchard, NA Varble… - Scientific Reports, 2024 - nature.com
Intratumoral injections have the potential for enhanced cancer treatment efficacy while
reducing costs and systemic exposure. However, intratumoral drug injections can result in …

In vivo imaging and pharmacokinetics of percutaneously injected ultrasound and X-ray imageable thermosensitive hydrogel loaded with doxorubicin versus free drug …

JF Delgado, AH Negussie, NA Varble, AS Mikhail… - PloS one, 2024 - journals.plos.org
Intratumoral injections often lack visibility, leading to unpredictable outcomes such as
incomplete tumor coverage, off-target drug delivery and systemic toxicities. This study …

Development of an X-Ray and Ultrasound Imageable Poloxamer-Based Gel for Image-Guided Local Percutaneous Drug Delivery

JFD Jimenez - 2024 - search.proquest.com
Intratumoral dosing of anti-cancer agents using long needles under image guidance faces
challenges due to the invisibility and unpredictable leakage of low viscous agents that leads …