Targeted delivery to bone and mineral deposits using bisphosphonate ligands
The high concentration of mineral present in bone and pathological calcifications is unique
compared with all other tissues and thus provides opportunity for targeted delivery of …
compared with all other tissues and thus provides opportunity for targeted delivery of …
Technetium (I) carbonyl complexes for nuclear medicine: Coordination-chemical aspect
GV Sidorenko, AE Miroslavov, MY Tyupina - Coordination Chemistry …, 2023 - Elsevier
Studies concerning the development of radiopharmaceuticals based on the Tc (I) carbonyl
core are considered from the coordination-chemical viewpoint. The coordination behavior of …
core are considered from the coordination-chemical viewpoint. The coordination behavior of …
Organometallic complexes for SPECT imaging and/or radionuclide therapy
GR Morais, A Paulo, I Santos - Organometallics, 2012 - ACS Publications
This article reviews Re and Tc organometallic chemistry and radiochemistry, focusing on the
most relevant aspects to design radiotools for molecular imaging and therapy. The review …
most relevant aspects to design radiotools for molecular imaging and therapy. The review …
A Bone-Seeking trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using 99mTc- and 177Lu-Labeled Tetrazines
A high yield synthesis of a novel, small molecule, bisphosphonate-modified trans-
cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures …
cyclooctene (TCO-BP, 2) that binds to regions of active bone metabolism and captures …
Bisphosphonates as radionuclide carriers for imaging or systemic therapy
Bisphosphonates (BP's), biologically stable analogs of naturally occurring pyrophosphates,
became the treatment of choice for pathologic conditions characterized by increased …
became the treatment of choice for pathologic conditions characterized by increased …
Imidazole-Based [2 + 1] Re(I)/99mTc(I) Complexes as Isostructural Nuclear and Optical Probes
A Yazdani, N Janzen, L Banevicius, S Czorny… - Inorganic …, 2015 - ACS Publications
The synthesis, stability, and photophysical properties of [2+ 1] Re (I)/Tc (I) complexes
derived from bipyridine and a series of imidazole derivatives were investigated as a means …
derived from bipyridine and a series of imidazole derivatives were investigated as a means …
Synthetic procedures leading towards aminobisphosphonates
E Chmielewska, P Kafarski - Molecules, 2016 - mdpi.com
Growing interest in the biological activity of aminobisphosphonates has stimulated the
development of methods for their synthesis. Although several general procedures were …
development of methods for their synthesis. Although several general procedures were …
Development of [90Y] DOTA-conjugated bisphosphonate for treatment of painful bone metastases
INTRODUCTION: Based on the concept of bifunctional radiopharmaceuticals, we have
previously developed 186Re-complex-conjugated bisphosphonate analogs for palliation of …
previously developed 186Re-complex-conjugated bisphosphonate analogs for palliation of …
Development of novel radiogallium-labeled bone imaging agents using oligo-aspartic acid peptides as carriers
K Ogawa, A Ishizaki, K Takai, Y Kitamura, T Kiwada… - PLoS …, 2013 - journals.plos.org
68Ga (T 1/2= 68 min, a generator-produced nuclide) has great potential as a radionuclide
for clinical positron emission tomography (PET). Because poly-glutamic and poly-aspartic …
for clinical positron emission tomography (PET). Because poly-glutamic and poly-aspartic …
Target-specific Tc (CO) 3-complexes for in vivo imaging
In recent years, the remarkable characteristics of the organometallic precursor fac-[M (CO) 3
(H 2 O) 3]+(M= Re, Tc) introduced by Alberto and co-workers brought renewed interest to the …
(H 2 O) 3]+(M= Re, Tc) introduced by Alberto and co-workers brought renewed interest to the …