Molecular imaging in drug discovery and development

M Rudin, R Weissleder - Nature reviews Drug discovery, 2003 - nature.com
Imaging sciences have grown exponentially during the past three decades, and many
techniques, such as magnetic resonance imaging, nuclear tomographic imaging and X-ray …

Magnetic resonance imaging in experimental models of brain disorders

RM Dijkhuizen, K Nicolay - Journal of Cerebral Blood Flow & …, 2003 - journals.sagepub.com
This review gives an overview of the application of magnetic resonance imaging (MRI) in
experimental models of brain disorders. MRI is a noninvasive and versatile imaging modality …

Three-dimensional cerebral vasculature of the CBA mouse brain: a magnetic resonance imaging and micro computed tomography study

A Dorr, JG Sled, N Kabani - Neuroimage, 2007 - Elsevier
Studies of mouse cerebral vasculature to date have focused on the circle of Willis without
examining the morphological distribution of blood vessels through the rest of the brain …

Cerebral artery dilatation maintains cerebral oxygenation at extreme altitude and in acute hypoxia—an ultrasound and MRI study

MH Wilson, MEG Edsell… - Journal of Cerebral …, 2011 - journals.sagepub.com
Transcranial Doppler is a widely used noninvasive technique for assessing cerebral artery
blood flow. All previous high altitude studies assessing cerebral blood flow (CBF) in the field …

4D microvascular imaging based on ultrafast Doppler tomography

C Demené, E Tiran, LA Sieu, A Bergel, JL Gennisson… - Neuroimage, 2016 - Elsevier
Abstract 4D ultrasound microvascular imaging was demonstrated by applying ultrafast
Doppler tomography (UFD-T) to the imaging of brain hemodynamics in rodents. In vivo real …

Age-dependent cerebrovascular abnormalities and blood flow disturbances in APP23 mice modeling Alzheimer's disease

N Beckmann, A Schuler, T Mueggler… - Journal of …, 2003 - jneurosci.org
Neuropathological changes associated with Alzheimer9s disease (AD) such as
amyloidplaques, cerebral amyloid angiopathy, and related pathologies are reproduced in …

Imaging of cerebrovascular pathology in animal models of Alzheimer's disease

J Klohs, M Rudin, DR Shimshek… - Frontiers in aging …, 2014 - frontiersin.org
In Alzheimer's disease (AD), vascular pathology may interact with neurodegeneration and
thus aggravate cognitive decline. As the relationship between these two processes is poorly …

Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic …

T Gerriets, E Stolz, M Walberer, C Muller, C Rottger… - Stroke, 2004 - ahajournals.org
Background and Purpose—Investigating focal cerebral ischemia requires animal models
that are relevant to human stroke. Complications and side effects are common among these …

High resolution magnetic resonance angiography non‐invasively reveals mouse strain differences in the cerebrovascular anatomy in vivo

N Beckmann - Magnetic Resonance in Medicine: An Official …, 2000 - Wiley Online Library
High resolution magnetic resonance angiography (MRA) revealed highly variable arterial
cerebrovascular structures in mice from different strains and within the same strain …

Contrast-enhanced magnetic resonance microangiography reveals remodeling of the cerebral microvasculature in transgenic ArcAβ mice

J Klohs, C Baltes, F Princz-Kranz, D Ratering… - Journal of …, 2012 - jneurosci.org
Amyloid-β (Aβ) deposition in the cerebral vasculature is accompanied by remodeling which
has a profound influence on vascular integrity and function. In the current study we have …