Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
BACKGROUND Liquid biopsies that are based on analysis of cell-free DNA from plasma
offer diagnostic information that is otherwise accessible conventionally through invasive …
offer diagnostic information that is otherwise accessible conventionally through invasive …
DNA sequencing at 40: past, present and future
This review commemorates the 40th anniversary of DNA sequencing, a period in which we
have already witnessed multiple technological revolutions and a growth in scale from a few …
have already witnessed multiple technological revolutions and a growth in scale from a few …
An ultrasensitive method for quantitating circulating tumor DNA with broad patient coverage
Circulating tumor DNA (ctDNA) is a promising biomarker for noninvasive assessment of
cancer burden, but existing ctDNA detection methods have insufficient sensitivity or patient …
cancer burden, but existing ctDNA detection methods have insufficient sensitivity or patient …
Liquid biopsies: genoty** circulating tumor DNA
Genoty** tumor tissue in search of somatic genetic alterations for actionable information
has become routine practice in clinical oncology. Although these sequence alterations are …
has become routine practice in clinical oncology. Although these sequence alterations are …
Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin
Nucleosome positioning varies between cell types. By deep sequencing cell-free DNA
(cfDNA), isolated from circulating blood plasma, we generated maps of genome-wide in vivo …
(cfDNA), isolated from circulating blood plasma, we generated maps of genome-wide in vivo …
The MIQE Guidelines: Minimum Information for Publication of Quantitative Real-Time PCR Experiments
Background: Currently, a lack of consensus exists on how best to perform and interpret
quantitative real-time PCR (qPCR) experiments. The problem is exacerbated by a lack of …
quantitative real-time PCR (qPCR) experiments. The problem is exacerbated by a lack of …
High-throughput droplet digital PCR system for absolute quantitation of DNA copy number
BJ Hindson, KD Ness, DA Masquelier… - Analytical …, 2011 - ACS Publications
Digital PCR enables the absolute quantitation of nucleic acids in a sample. The lack of
scalable and practical technologies for digital PCR implementation has hampered the …
scalable and practical technologies for digital PCR implementation has hampered the …
Analytical and clinical validation of a microbial cell-free DNA sequencing test for infectious disease
Thousands of pathogens are known to infect humans, but only a fraction are readily
identifiable using current diagnostic methods. Microbial cell-free DNA sequencing offers the …
identifiable using current diagnostic methods. Microbial cell-free DNA sequencing offers the …
The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
Colorectal tumours that are wild type for KRAS are often sensitive to EGFR blockade, but
almost always develop resistance within several months of initiating therapy,. The …
almost always develop resistance within several months of initiating therapy,. The …
[HTML][HTML] Noninvasive prenatal screening for fetal aneuploidy, 2016 update: a position statement of the American College of Medical Genetics and Genomics
AR Gregg, BG Skotko, JL Benkendorf, KG Monaghan… - Genetics in …, 2016 - Elsevier
Disclaimer: This statement is designed primarily as an educational resource for clinicians to
help them provide quality medical services. Adherence to this statement is completely …
help them provide quality medical services. Adherence to this statement is completely …