Computation through neural population dynamics

S Vyas, MD Golub, D Sussillo… - Annual review of …, 2020‏ - annualreviews.org
Significant experimental, computational, and theoretical work has identified rich structure
within the coordinated activity of interconnected neural populations. An emerging challenge …

Quantifying behavior to understand the brain

TD Pereira, JW Shaevitz, M Murthy - Nature neuroscience, 2020‏ - nature.com
Over the past years, numerous methods have emerged to automate the quantification of
animal behavior at a resolution not previously imaginable. This has opened up a new field of …

Inferring single-trial neural population dynamics using sequential auto-encoders

C Pandarinath, DJ O'Shea, J Collins, R Jozefowicz… - Nature …, 2018‏ - nature.com
Neuroscience is experiencing a revolution in which simultaneous recording of thousands of
neurons is revealing population dynamics that are not apparent from single-neuron …

A disentangled recognition and nonlinear dynamics model for unsupervised learning

M Fraccaro, S Kamronn, U Paquet… - Advances in neural …, 2017‏ - proceedings.neurips.cc
This paper takes a step towards temporal reasoning in a dynamically changing video, not in
the pixel space that constitutes its frames, but in a latent space that describes the non-linear …

An approximate line attractor in the hypothalamus encodes an aggressive state

A Nair, T Karigo, B Yang, S Ganguli, MJ Schnitzer… - Cell, 2023‏ - cell.com
The hypothalamus regulates innate social behaviors, including mating and aggression.
These behaviors can be evoked by optogenetic stimulation of specific neuronal …

Unsupervised discovery of demixed, low-dimensional neural dynamics across multiple timescales through tensor component analysis

AH Williams, TH Kim, F Wang, S Vyas, SI Ryu… - Neuron, 2018‏ - cell.com
Perceptions, thoughts, and actions unfold over millisecond timescales, while learned
behaviors can require many days to mature. While recent experimental advances enable …

Unsupervised identification of the internal states that shape natural behavior

AJ Calhoun, JW Pillow, M Murthy - Nature neuroscience, 2019‏ - nature.com
Internal states shape stimulus responses and decision-making, but we lack methods to
identify them. To address this gap, we developed an unsupervised method to identify …

Causal evidence of a line attractor encoding an affective state

A Vinograd, A Nair, JH Kim, SW Linderman… - Nature, 2024‏ - nature.com
Continuous attractors are an emergent property of neural population dynamics that have
been hypothesized to encode continuous variables such as head direction and eye …

Multiregion neuronal activity: the forest and the trees

TA Machado, IV Kauvar, K Deisseroth - Nature Reviews Neuroscience, 2022‏ - nature.com
The past decade has witnessed remarkable advances in the simultaneous measurement of
neuronal activity across many brain regions, enabling fundamentally new explorations of the …

Encoding of female mating dynamics by a hypothalamic line attractor

M Liu, A Nair, N Coria, SW Linderman, DJ Anderson - Nature, 2024‏ - nature.com
Females exhibit complex, dynamic behaviours during mating with variable sexual receptivity
depending on hormonal status,,–. However, how their brains encode the dynamics of mating …