Pancreatic cancer is an increasingly common cause of cancer mortality with a tight
correspondence between disease mortality and incidence. Furthermore, it is usually …

Tumorigenesis is a highly complex process, involving many interrelated and cross-acting
signalling pathways. One such pathway that has garnered much attention in the field of …

Objective Intratumor heterogeneity drives cancer progression and therapy resistance.
However, it has yet to be determined whether and how subpopulations of cancer cells …

Background Chemoresistance is the main reason for the poor prognosis of pancreatic ductal
adenocarcinoma (PDAC). Thus, there is an urgent need to screen out new targets and …

Pancreatic cancer (PDAC) is one of the deadliest types of human cancers, owing to late
stage at presentation and pervasive therapeutic resistance. The extensive tumour …

Bidirectional signal transduction between tumor epithelial cells and tumor microenvironment
(TME) is important for tumor development. Here we show that Lin28b/let-7 pathway is …

The role of the evolutionarily conserved Wnt signaling pathway is well documented in
several cellular processes, such as cell proliferation, differentiation, cell motility, and …

Human pancreatic cancer is characterized by the molecular diversity encompassing native
duct-like and squamous cell-like identities, but mechanisms underlying squamous …

Mitochondria are hubs where bioenergetics, redox homeostasis, and anabolic metabolism
pathways integrate through a tightly coordinated flux of metabolites. The contributions of …

Simple Summary Obesity is recognized as a chronic progressive disease and risk factor for
many human diseases. The high and increasing number of obese people may underlie the …