Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the
generation of induced pluripotent stem cells, have delivered preliminary evidence that …

In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

The recent availability of comprehensive, brain-wide gene expression atlases such as the
Allen Human Brain Atlas (AHBA) has opened new opportunities for understanding how …

Disease incidences increase with age, but the molecular characteristics of ageing that lead
to increased disease susceptibility remain inadequately understood. Here we perform a …

Biomarkers of aging can be used to assess the health of individuals and to study aging and
age-related diseases. We generate a large dataset of genome-wide RNA-seq profiles of …

The ability to estimate the age of the donor from recovered biological material at a crime
scene can be of substantial value in forensic investigations. Aging can be complex and is …

Single-cell transcriptomic studies have identified a conserved set of neocortical cell types
from small postmortem cohorts. We extended these efforts by assessing cell type variation …

Transcriptomic imputation approaches combine eQTL reference panels with large-scale
genotype data in order to test associations between disease and gene expression. These …

Aging is a major risk factor in many forms of late-onset neurodegenerative disorders. The
ability to recapitulate age-related characteristics of human neurons in culture will offer …