In the hippocampus GABAergic local circuit inhibitory interneurons represent only~ 10–15%
of the total neuronal population; however, their remarkable anatomical and physiological …

Parvalbumin is a calcium-binding protein present in inhibitory interneurons that play an
essential role in regulating many physiological processes, such as intracellular signaling …

GABAergic interneurons of the parvalbumin-positive fast-spiking basket cells subtype (PV
INs) are important regulators of cortical network excitability and of gamma oscillations …

Epilepsy is a common brain disorder characterized by recurrent epileptic seizures with
neuronal hyperexcitability. Apart from the classical imbalance between excitatory …

Background Previous studies indicated the involvement of cholinergic neurons in seizure;
however, the specific role of the medial septum (MS)-hippocampus cholinergic circuit in …

As an important second messenger, the calcium ion (Ca2+) plays a vital role in normal brain
function and in the pathophysiological process of different neurodegenerative diseases …

Parvalbumin (PV)-expressing interneurons exert powerful inhibitory effects on the normal
cortical network; thus optogenetic activation of PV interneurons may also possess …

Measurements of neuronal signals during human seizure activity and evoked epileptic
activity in experimental models suggest that, in these pathological states, the individual …

Neural dynamics preceding seizures are of interest because they may shed light on
mechanisms of seizure generation and could be predictive. In healthy animals, hippocampal …

Recent reports in human demonstrate a role of theta–gamma coupling in memory for spatial
episodes and a lack of coupling in people experiencing temporal lobe epilepsy, but the …