The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis

MD Scofield, JA Heinsbroek, CD Gipson… - Pharmacological …, 2016 - Elsevier
The nucleus accumbens is a major input structure of the basal ganglia and integrates
information from cortical and limbic structures to mediate goal-directed behaviors. Chronic …

Magnetically enhanced nucleic acid delivery. Ten years of magnetofection—Progress and prospects

C Plank, O Zelphati, O Mykhaylyk - Advanced drug delivery reviews, 2011 - Elsevier
Nucleic acids carry the building plans of living systems. As such, they can be exploited to
make cells produce a desired protein, or to shut down the expression of endogenous genes …

Integrin-linked kinase–essential roles in physiology and cancer biology

PC McDonald, AB Fielding… - Journal of cell …, 2008 - journals.biologists.com
Integrin-linked kinase (ILK) is a multifunctional intracellular effector of cell-matrix interactions
and regulates many cellular processes, including growth, proliferation, survival …

The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!

SA Wickström, A Lange, E Montanez, R Fässler - The EMBO journal, 2010 - embopress.org
Dynamic interactions of cells with their environment regulate multiple aspects of tissue
morphogenesis and function. Integrins are the major class of cell surface receptors that …

Integrin-linked kinase (ILK): the known vs. the unknown and perspectives

A Górska, AJ Mazur - Cellular and Molecular Life Sciences, 2022 - Springer
Integrin-linked kinase (ILK) is a multifunctional molecular actor in cell–matrix interactions,
cell adhesion, and anchorage-dependent cell growth. It combines functions of a signal …

Reelin stabilizes the actin cytoskeleton of neuronal processes by inducing n-cofilin phosphorylation at serine3

X Chai, E Förster, S Zhao, HH Bock… - Journal of …, 2009 - Soc Neuroscience
The extracellular matrix protein Reelin, secreted by Cajal-Retzius cells in the marginal zone
of the cortex, controls the radial migration of cortical neurons. Reelin signaling involves the …

Triggering biological processes: methods and applications of photocaged peptides and proteins

AE Mangubat-Medina, ZT Ball - Chemical Society Reviews, 2021 - pubs.rsc.org
There has been a significant push in recent years to deploy fundamental knowledge and
methods of photochemistry toward biological ends. Photoreactive groups have enabled …

The sarcomeric Z‐disc and Z‐discopathies

R Knöll, B Buyandelger, M Lab - BioMed Research …, 2011 - Wiley Online Library
The sarcomeric Z‐disc defines the lateral borders of the sarcomere and has primarily been
seen as a structure important for mechanical stability. This view has changed dramatically …

Understanding the molecular basis of cardiomyopathy

ML Bang, J Bogomolovas… - American Journal of …, 2022 - journals.physiology.org
Inherited cardiomyopathies are a major cause of mortality and morbidity worldwide and can
be caused by mutations in a wide range of proteins located in different cellular …

The tetrapartite synapse: extracellular matrix remodeling contributes to corticoaccumbens plasticity underlying drug addiction

ACW Smith, MD Scofield, PW Kalivas - Brain research, 2015 - Elsevier
Synaptic plasticity has long been known to involve three key elements of neuropil, the
presynapse, the postsynapse and adjacent glia. Here we review the role of the extracellular …