Oxidative stress is a major cause of morbidity and mortality in human health and disease. In
this review, we focus on the Forkhead Box (Fox) subclass O3 (FoxO3), an extensively …

Cellular senescence has long been considered a permanent state of cell cycle arrest
occurring in proliferating cells subject to different stressors, used as a cellular defense …

Manganese (Mn), as one of the environmental risk factors for Parkinson's disease (PD), has
been widely studied. Though autophagy dysfunction and neuroinflammation mainly are …

Aging increases the risk of age-related diseases, imposing substantial healthcare and
personal costs. Targeting fundamental aging mechanisms pharmacologically can promote …

Background High glucose levels are a primary cause of diabetes-associated cellular
dysfunction and tissue damage. Muscles are the key insulin target organ and therefore, have …

Spaceflight-induced osteoporosis (SFOP) is a detrimental healthcare consequence during
spaceflight. Weightlessness and ionizing radiation were main environmental factors that …

Hormesis is reported for various environmental pollutants and is believed to be a highly
common phenomenon. Caenorhabditis elegans nematodes have advantages of easy …

Background CDGSH iron-sulfur domain-containing protein 2 (CISD2), a pro-longevity gene,
mediates healthspan in mammals. CISD2 is down-regulated during aging. Furthermore, a …

Intervertebral disc degeneration (IVDD) is a common cause of low back pain. Procyanidin
C1 (PCC1) has been demonstrated to exert a protective effect on nucleus pulposus (NP) …

The study of aging is an important topic in contemporary research. Considering the
demographic changes and the resulting shifts towards an older population, it is of great …