Precision medicine and nucleotide-based therapeutics to treat MASH

A Caddeo, S Romeo - Clinical and Molecular Hepatology, 2024 - e-cmh.org
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a complex multifactorial
disease and becoming the leading cause of liver-related morbidity and mortality. MASLD …

Unraveling Mechanisms of Genetic Risks in Metabolic Dysfunction–Associated Steatotic Liver Diseases: A Pathway to Precision Medicine

X Zhang, KM Chang, J Yu… - Annual Review of …, 2025 - annualreviews.org
Metabolic dysfunction–associated steatotic liver disease (MASLD) is a growing global health
problem, affecting∼ 1 billion people. This condition is well established to have a heritable …

[HTML][HTML] IL32 downregulation lowers triglycerides and type I collagen in di-lineage human primary liver organoids

K Sasidharan, A Caddeo, O Jamialahmadi, FR Noto… - Cell Reports …, 2024 - cell.com
Steatotic liver disease (SLD) prevails as the most common chronic liver disease yet lack
approved treatments due to incomplete understanding of pathogenesis. Recently, elevated …

Exploring the impact of lipid droplets on the evolution and progress of hepatocarcinoma

S Maurotti, N Geirola, M Frosina, A Mirarchi… - Frontiers in Cell and …, 2024 - frontiersin.org
Over the past 10 years, the biological role of lipid droplets (LDs) has gained significant
attention in the context of both physiological and pathological conditions. Considerable …

[HTML][HTML] The pivotal role of the membrane-bound O-acyltransferase domain containing 7 in non-alcoholic fatty liver disease

P Chandrasekaran, R Weiskirchen - Livers, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a common and prevalent disorder affecting 25
percent of the adults in the United States and 32 percent of adults globally. It is one of the …

[HTML][HTML] 3D culture models to study pathophysiology of steatotic liver disease

A Caddeo, S Maurotti, L Kovooru, S Romeo - Atherosclerosis, 2024 - Elsevier
Steatotic liver disease (SLD) refers to a spectrum of diseases caused by hepatic lipid
accumulation. SLD has emerged as the leading cause of chronic liver disease worldwide …

Lipid droplets in steatotic liver disease

J Bilson, E Scorletti - Current Opinion in Clinical Nutrition & …, 2024 - journals.lww.com
Much more than a histological feature, lipid droplets are complex heterogenous organelles
crucial to cellular metabolism with important causative roles in the development and …

Genetic predisposition to metabolic dysfunction-associated fatty liver disease

OE Abaturov, AO Nikulina - CHILDS HEALTH, 2024 - childshealth.zaslavsky.com.ua
The literature review highlights the issue of genetic risk factors associated with the
development of metabolic dysfunction-associated fatty liver disease. Human genetic …

[HTML][HTML] TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant decreases PNPLA3-mediated PUFA transfer to promote hepatic …

A Caddeo, RM Mancina - Clinical and Molecular Hepatology, 2024 - pmc.ncbi.nlm.nih.gov
TM6SF2 and PNPLA3: A potential dynamic duo?: Editorial on “TM6SF2 E167K variant
decreases PNPLA3-mediated PUFA transfer to promote hepatic steatosis and injury in MASLD” …

[PDF][PDF] TM6SF2 and PNPLA3: a potential dynamic duo?

A Caddeo, RM Mancina - Clinical and Molecular Hepatology, 2024 - e-cmh.org
Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) is the most prevalent
chronic liver disease and the major cause of liver-related mortality worldwide 1. MASLD is …