Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biology

A Limone, V Maggisano, D Sarnataro… - Cellular and Molecular …, 2023 - Springer
The cellular prion protein (PrPC) is well-known for its involvement, under its pathogenic
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …

Prion protein: From physiology to cancer biology

M Mehrpour, P Codogno - Cancer letters, 2010 - Elsevier
Prion protein (PrPc) was originally viewed solely as being involved in prion disease, but now
several intriguing lines of evidence have emerged indicating that it plays a fundamental role …

Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor

Y Fujimura, M Sumida, K Sugihara, S Tsukamoto… - PLoS …, 2012 - journals.plos.org
Background We previously identified the 67-kDa laminin receptor (67LR) as the cell-surface
receptor conferring the major green tea polyphenol (–)-epigallocatechin-3-O-gallate (EGCG) …

Molecular modification, structural characterization, and biological activity of xylans

M Zhang, A Zhan, Y Ye, C Liu, F Hang, K Li, J Li - Carbohydrate Polymers, 2021 - Elsevier
The differences in the source and structure of xylans make them have various biological
activities. However, due to their inherent structural limitations, the various biological activities …

Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction

DG Kim, JY Lee, NH Kwon, P Fang, Q Zhang… - Nature chemical …, 2014 - nature.com
Abstract Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates
to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor …

Multiple functions of the 37/67-kd laminin receptor make it a suitable target for novel cancer gene therapy

J Scheiman, JC Tseng, Y Zheng, D Meruelo - Molecular Therapy, 2010 - cell.com
The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the
40S ribosomal subunit and also localizes to the cell membrane to interact with the …

Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease

K Jovanovic, CJ Chetty, T Khumalo… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: The 37/67 kDa high-affinity laminin receptor (laminin receptor precursor/laminin
receptor, LRP/LR) is a multi-faceted cellular receptor. It plays a vital role in the malignancy of …

Tumour cell blebbing and extracellular vesicle shedding: Key role of matrikines and ribosomal protein SA

B Brassart, J Da Silva, M Donet, E Seurat… - British journal of …, 2019 - nature.com
Background Carcinogenesis occurs in elastin-rich tissues and leads to local inflammation
and elastolytic proteinase release. This contributes to bioactive matrix fragment (Matrikine) …

Anti-LRP/LR-specific antibody IgG1-iS18 significantly reduces adhesion and invasion of metastatic lung, cervix, colon and prostate cancer cells

A Omar, U Reusch, S Knackmuss, M Little… - Journal of molecular …, 2012 - Elsevier
The 37-kDa/67-kDa laminin receptor [laminin receptor precursor/high-affinity laminin
receptor (LRP/LR)] is thought to play a major role in invasion and adhesion, key components …

Patented therapeutic approaches targeting LRP/LR for cancer treatment

L Vania, G Morris, TC Otgaar, MJ Bignoux… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: The ubiquitously expressed 37 kDa/67 kDa high-affinity laminin receptor
(laminin receptor precursor/laminin receptor, LRP/LR) is a protein found to play several roles …