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Emerging roles of the cellular prion protein (PrPC) and 37/67 kDa laminin receptor (RPSA) interaction in cancer biology
A Limone, V Maggisano, D Sarnataro… - Cellular and Molecular …, 2023 - Springer
The cellular prion protein (PrPC) is well-known for its involvement, under its pathogenic
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …
protease-resistant form (PrPSc), in a group of neurodegenerative diseases, known as prion …
Prion protein: From physiology to cancer biology
Prion protein (PrPc) was originally viewed solely as being involved in prion disease, but now
several intriguing lines of evidence have emerged indicating that it plays a fundamental role …
several intriguing lines of evidence have emerged indicating that it plays a fundamental role …
Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor
Y Fujimura, M Sumida, K Sugihara, S Tsukamoto… - PLoS …, 2012 - journals.plos.org
Background We previously identified the 67-kDa laminin receptor (67LR) as the cell-surface
receptor conferring the major green tea polyphenol (–)-epigallocatechin-3-O-gallate (EGCG) …
receptor conferring the major green tea polyphenol (–)-epigallocatechin-3-O-gallate (EGCG) …
Molecular modification, structural characterization, and biological activity of xylans
M Zhang, A Zhan, Y Ye, C Liu, F Hang, K Li, J Li - Carbohydrate Polymers, 2021 - Elsevier
The differences in the source and structure of xylans make them have various biological
activities. However, due to their inherent structural limitations, the various biological activities …
activities. However, due to their inherent structural limitations, the various biological activities …
Chemical inhibition of prometastatic lysyl-tRNA synthetase–laminin receptor interaction
Abstract Lysyl-tRNA synthetase (KRS), a protein synthesis enzyme in the cytosol, relocates
to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor …
to the plasma membrane after a laminin signal and stabilizes a 67-kDa laminin receptor …
Multiple functions of the 37/67-kd laminin receptor make it a suitable target for novel cancer gene therapy
J Scheiman, JC Tseng, Y Zheng, D Meruelo - Molecular Therapy, 2010 - cell.com
The 37/67-kd laminin receptor, LAMR, is a multifunctional protein that associates with the
40S ribosomal subunit and also localizes to the cell membrane to interact with the …
40S ribosomal subunit and also localizes to the cell membrane to interact with the …
Novel patented therapeutic approaches targeting the 37/67 kDa laminin receptor for treatment of cancer and Alzheimer's disease
K Jovanovic, CJ Chetty, T Khumalo… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: The 37/67 kDa high-affinity laminin receptor (laminin receptor precursor/laminin
receptor, LRP/LR) is a multi-faceted cellular receptor. It plays a vital role in the malignancy of …
receptor, LRP/LR) is a multi-faceted cellular receptor. It plays a vital role in the malignancy of …
Tumour cell blebbing and extracellular vesicle shedding: Key role of matrikines and ribosomal protein SA
B Brassart, J Da Silva, M Donet, E Seurat… - British journal of …, 2019 - nature.com
Background Carcinogenesis occurs in elastin-rich tissues and leads to local inflammation
and elastolytic proteinase release. This contributes to bioactive matrix fragment (Matrikine) …
and elastolytic proteinase release. This contributes to bioactive matrix fragment (Matrikine) …
Anti-LRP/LR-specific antibody IgG1-iS18 significantly reduces adhesion and invasion of metastatic lung, cervix, colon and prostate cancer cells
A Omar, U Reusch, S Knackmuss, M Little… - Journal of molecular …, 2012 - Elsevier
The 37-kDa/67-kDa laminin receptor [laminin receptor precursor/high-affinity laminin
receptor (LRP/LR)] is thought to play a major role in invasion and adhesion, key components …
receptor (LRP/LR)] is thought to play a major role in invasion and adhesion, key components …
Patented therapeutic approaches targeting LRP/LR for cancer treatment
L Vania, G Morris, TC Otgaar, MJ Bignoux… - Expert opinion on …, 2019 - Taylor & Francis
Introduction: The ubiquitously expressed 37 kDa/67 kDa high-affinity laminin receptor
(laminin receptor precursor/laminin receptor, LRP/LR) is a protein found to play several roles …
(laminin receptor precursor/laminin receptor, LRP/LR) is a protein found to play several roles …