The full spectrum of human naive T cells
T van den Broek, JAM Borghans… - Nature Reviews …, 2018 - nature.com
Naive T cells have long been regarded as a developmentally synchronized and fairly
homogeneous and quiescent cell population, the size of which depends on age, thymic …
homogeneous and quiescent cell population, the size of which depends on age, thymic …
Aging of the T cell compartment in mice and humans: from no naive expectations to foggy memories
J Nikolich-Žugich - The Journal of Immunology, 2014 - journals.aai.org
Until the mid-20th century, infectious diseases were the major cause of morbidity and
mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced …
mortality in humans. Massive vaccination campaigns, antibiotics, antivirals, and advanced …
McPAS-TCR: a manually curated catalogue of pathology-associated T cell receptor sequences
N Tickotsky, T Sagiv, J Prilusky, E Shifrut… - …, 2017 - academic.oup.com
Motivation While growing numbers of T cell receptor (TCR) repertoires are being mapped by
high-throughput sequencing, existing methods do not allow for computationally connecting a …
high-throughput sequencing, existing methods do not allow for computationally connecting a …
Aging promotes reorganization of the CD4 T cell landscape toward extreme regulatory and effector phenotypes
Age-associated changes in CD4 T-cell functionality have been linked to chronic
inflammation and decreased immunity. However, a detailed characterization of CD4 T cell …
inflammation and decreased immunity. However, a detailed characterization of CD4 T cell …
Vedolizumab is associated with changes in innate rather than adaptive immunity in patients with inflammatory bowel disease
Objective Vedolizumab, a monoclonal antibody directed against the integrin heterodimer
α4β7, is approved for the treatment of Crohn's disease and ulcerative colitis. The efficacy of …
α4β7, is approved for the treatment of Crohn's disease and ulcerative colitis. The efficacy of …
Myocardial aging as a T-cell–mediated phenomenon
GC Ramos, A van den Berg… - Proceedings of the …, 2017 - National Acad Sciences
In recent years, the myocardium has been rediscovered under the lenses of immunology,
and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with …
and lymphocytes have been implicated in the pathogenesis of cardiomyopathies with …
T cell receptor repertoires of mice and humans are clustered in similarity networks around conserved public CDR3 sequences
Diversity of T cell receptor (TCR) repertoires, generated by somatic DNA rearrangements, is
central to immune system function. However, the level of sequence similarity of TCR …
central to immune system function. However, the level of sequence similarity of TCR …
Single-cell lineage map** of a diverse virus-specific naive CD4 T cell repertoire
Tracking how individual naive T cells from a natural TCR repertoire clonally expand,
differentiate, and make lineage choices in response to an infection has not previously been …
differentiate, and make lineage choices in response to an infection has not previously been …
[HTML][HTML] New approaches to understanding the immune response to vaccination and infection
The immune system is a network of specialized cell types and tissues that communicates via
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
cytokines and direct contact, to orchestrate specific types of defensive responses. Until …
T‐cell receptor and B‐cell receptor repertoire profiling in adaptive immunity
A Minervina, M Pogorelyy… - Transplant International, 2019 - Wiley Online Library
B‐cell receptors and T‐cell receptors are the key molecules responsible for specific antigen
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …
recognition in adaptive immunity. The huge diversity of immune receptor repertoires …