Traumatic brain injury: progress and challenges in prevention, clinical care, and research

AIR Maas, DK Menon, GT Manley, M Abrams… - The Lancet …, 2022 - thelancet.com
Executive summary Traumatic brain injury (TBI) has the highest incidence of all common
neurological disorders, and poses a substantial public health burden. TBI is increasingly …

Endoplasmic reticulum stress and the unfolded protein response: emerging regulators in progression of traumatic brain injury

Y Yang, D Lu, M Wang, G Liu, Y Feng, Y Ren… - Cell death & …, 2024 - nature.com
Traumatic brain injury (TBI) is a common trauma with high mortality and disability rates
worldwide. However, the current management of this disease is still unsatisfactory …

Opportunities and challenges of microneedle electrochemical sensors for interstitial fluid detection

Y Dong, S Mao, S Chen, J Ma… - TrAC Trends in …, 2024 - Elsevier
Microneedle (MN) electrochemical sensors offer new strategies for personalized medicine
and point-to-point medical testing, providing new opportunities for disease diagnosis and …

Clinical descriptors of disease trajectories in patients with traumatic brain injury in the intensive care unit (CENTER-TBI): a multicentre observational cohort study

CAI Åkerlund, A Holst, S Bhattacharyay… - The Lancet …, 2024 - thelancet.com
Background Patients with traumatic brain injury are a heterogeneous population, and the
most severely injured individuals are often treated in an intensive care unit (ICU). The …

[HTML][HTML] Blood biomarkers for traumatic brain injury: A narrative review of current evidence

I Hossain, N Marklund, E Czeiter, P Hutchinson, A Buki - Brain and spine, 2024 - Elsevier
Introduction A blood-based biomarker (BBBM) test could help to better stratify patients with
traumatic brain injury (TBI), reduce unnecessary imaging, to detect and treat secondary …

Brain age prediction using combined deep convolutional neural network and multi-layer perceptron algorithms

Y Joo, E Namgung, H Jeong, I Kang, J Kim, S Oh… - Scientific Reports, 2023 - nature.com
The clinical applications of brain age prediction have expanded, particularly in anticipating
the onset and prognosis of various neurodegenerative diseases. In the current study, we …

[HTML][HTML] White matter damage and degeneration in traumatic brain injury

RC Armstrong, GM Sullivan, DP Perl, JD Rosarda… - Trends in …, 2024 - cell.com
Traumatic brain injury (TBI) is a complex condition that can resolve over time but all too often
leads to persistent symptoms, and the risk of poor patient outcomes increases with aging …

The role of astrocyte in neuroinflammation in traumatic brain injury

L He, R Zhang, M Yang, M Lu - … et Biophysica Acta (BBA)-Molecular Basis …, 2024 - Elsevier
Traumatic brain injury (TBI), a significant contributor to mortality and morbidity worldwide, is
a devastating condition characterized by initial mechanical damage followed by subsequent …

The 2022 lady estelle wolfson lectureship on neurofilaments

A Petzold - Journal of neurochemistry, 2022 - Wiley Online Library
Neurofilament proteins (Nf) have been validated and established as a reliable body fluid
biomarker for neurodegenerative pathology. This review covers seven Nf isoforms, Nf light …

Early systemic insults following traumatic brain injury: association with biomarker profiles, therapy for intracranial hypertension, and neurological outcomes—an …

C Robba, F Graziano, E Picetti, C Åkerlund… - Intensive care …, 2024 - Springer
Purpose We analysed the impact of early systemic insults (hypoxemia and hypotension, SIs)
on brain injury biomarker profiles, acute care requirements during intensive care unit (ICU) …