Potential and limits of a colloid approach to protein solutions
A Stradner, P Schurtenberger - Soft Matter, 2020 - pubs.rsc.org
Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a
significant part of the early colloid literature was focused on protein solutions. However, it …
significant part of the early colloid literature was focused on protein solutions. However, it …
Viscosity control of protein solution by small solutes: a review
Viscosity of protein solution is one of the most troublesome issues for the high-concentration
formulation of protein drugs. In this review, we summarize the practical methods that …
formulation of protein drugs. In this review, we summarize the practical methods that …
Recent progresses of understanding the viscosity of concentrated protein solutions
Highlights•Colloidal approaches to understand concentrated globular protein
solutions.•Structure-viscosity relationship for concentrated monoclonal antibody …
solutions.•Structure-viscosity relationship for concentrated monoclonal antibody …
Biophysical determinants for the viscosity of concentrated monoclonal antibody solutions
Monoclonal antibodies (mAbs) are particularly relevant for therapeutics due to their high
specificity and versatility, and mAb-based drugs are hence used to treat numerous diseases …
specificity and versatility, and mAb-based drugs are hence used to treat numerous diseases …
High-resolution neutron spectroscopy using backscattering and neutron spin-echo spectrometers in soft and hard condensed matter
JS Gardner, G Ehlers, A Faraone… - Nature Reviews …, 2020 - nature.com
The instruments best suited to performing high-energy-resolution neutron spectroscopy are
spin-echo spectrometers and backscattering spectrometers. The development of these …
spin-echo spectrometers and backscattering spectrometers. The development of these …
How well do low-and high-concentration protein interactions predict solution viscosities of monoclonal antibodies?
Protein-protein interactions (PPI) and solution viscosities were measured at low and high
protein concentrations under a range of formulation conditions for 4 different monoclonal …
protein concentrations under a range of formulation conditions for 4 different monoclonal …
Monitoring of ultra-and diafiltration processes by Kalman-filtered Raman measurements
Monitoring the protein concentration and buffer composition during the Ultrafiltration/
Diafiltration (UF/DF) step enables the further automation of biopharmaceutical production …
Diafiltration (UF/DF) step enables the further automation of biopharmaceutical production …
Characterizing experimental monoclonal antibody interactions and clustering using a coarse-grained simulation library and a viscosity model
A Chowdhury, N Manohar, G Guruprasad… - The Journal of …, 2023 - ACS Publications
Attractive protein–protein interactions in concentrated monoclonal antibody (mAb) solutions
may lead to the formation of clusters that increase viscosity. Here, we propose an analytical …
may lead to the formation of clusters that increase viscosity. Here, we propose an analytical …
Colloidal systems with a short-range attraction and long-range repulsion: Phase diagrams, structures, and dynamics
Colloidal systems with both a short-range attraction and long-range repulsion (SALR) have
rich phases compared with the traditional hard sphere systems or sticky hard sphere …
rich phases compared with the traditional hard sphere systems or sticky hard sphere …
Subclass Effects on Self-Association and Viscosity of Monoclonal Antibodies at High Concentrations
AA Chowdhury, N Manohar, MA Witek… - Molecular …, 2023 - ACS Publications
The effects of a subclass of monoclonal antibodies (mAbs) on protein–protein interactions,
formation of reversible oligomers (clusters), and viscosity (η) are not well understood at high …
formation of reversible oligomers (clusters), and viscosity (η) are not well understood at high …