Galectins are a family of small, highly conserved, molecular effectors that mediate various
biological processes, including chemotaxis and angiogenesis, and that function by …

Galectins, a family of evolutionarily conserved glycan-binding proteins, play key roles in
diverse biological processes including tissue repair, adipogenesis, immune cell …

Among mammary tumor-infiltrating immune cells, the highest expression of podoplanin
(PDPN) is found in a subset of tumor-associated macrophages (TAMs). We hereby …

Galectins are soluble glycan-binding proteins that interact with a wide range of glycoproteins
and glycolipids and modulate a broad spectrum of physiological and pathological …

Receptor tyrosine kinases (RTKs) constitute a large group of cell surface proteins that
mediate communication of cells with extracellular environment. RTKs recognize external …

Changes in cell growth and metabolism are affected by the surrounding environmental
factors to adapt to the cell's most appropriate growth model. However, abnormal cell …

Abstract Galectin-8 (Gal-8), a 'tandem-repeat'-type galectin, has been described as a
modulator of cellular functions including adhesion, spreading, growth arrest, apoptosis …

Glycosylation consists in the covalent, enzyme mediated, attachment of sugar chains to
proteins and lipids. A large proportion of membrane and secreted proteins are indeed …

Epithelial to mesenchymal transition (EMT) is the process whereby a polarized epithelial cell
ceases to maintain cell-cell contacts, loses expression of characteristic epithelial cell …

The reading of glycan-encoded signals by tissue lectins is considered a major route of the
flow of biological information in many (patho) physiological processes. The arising …