An elevated level of total homocysteine (tHcy) in blood, denoted hyperhomocysteinemia, is
emerging as a prevalent and strong risk factor for atherosclerotic vascular disease in the …

The annual incidence of venous thrombosis, one of the leading causes of mortality and
morbidity, increases from 1 per 100,000 during childhood to 1 per 100 in old age. 1 In this …

Objective.—To determine the risk of elevated total homocysteine (tHcy) levels for
arteriosclerotic vascular disease, estimate the reduction of tHcy by folic acid, and calculate …

Recently, we showed that homozygosity for the common 677 (C→ T) mutation in the
methylenetetrahydrofolate reductase (MTHFR) gene, causing thermolability of the enzyme …

Background Previous studies have suggested that hyperhomocysteinemia may be a risk
factor for venous thrombosis. To assess the risk of venous thrombosis associated with …

Heightened rates of both cardiovascular (CV) events and subclinical atherosclerosis,
documented by imaging and vascular function techniques are well established in systemic …

ContextData on the recurrence rate of venous thrombotic events and the effect of several risk
factors, including thrombophilia, remain controversial. The potential benefit of screening for …

Context: It has been suggested that elevated total plasma homocysteine levels are
associated with the risk of venous thrombosis. Objective: To assess the relationship of …

Periconceptional folate supplementation reduces the risk of neural-tube defects. We studied
the frequency of the 677C→ T mutation in the 5, 10–methylenetetrahydrofolate reductase …

Although familial clustering of venous thromboembolic events was observed at the start of
this century, it was not until the late nineteenseventies before our insight into the …