A decade of genome-wide association studies for coronary artery disease: the challenges ahead
J Erdmann, T Kessler, L Munoz Venegas… - Cardiovascular …, 2018 - academic.oup.com
In this review, we summarize current knowledge on the genetics of coronary artery disease,
based on 10 years of genome-wide association studies. The discoveries began with …
based on 10 years of genome-wide association studies. The discoveries began with …
Applications and limitations of mouse models for understanding human atherosclerosis
Most of the biological understanding of mechanisms underlying coronary artery disease
(CAD) derives from studies of mouse models. The identification of multiple CAD loci and …
(CAD) derives from studies of mouse models. The identification of multiple CAD loci and …
Cell-autonomous regulation of complement C3 by factor H limits macrophage efferocytosis and exacerbates atherosclerosis
Complement factor H (CFH) negatively regulates consumption of complement component 3
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …
Integration of multi-omics data from mouse diversity panel highlights mitochondrial dysfunction in non-alcoholic fatty liver disease
The etiology of non-alcoholic fatty liver disease (NAFLD), the most common form of chronic
liver disease, is poorly understood. To understand the causal mechanisms underlying …
liver disease, is poorly understood. To understand the causal mechanisms underlying …
Systems genetics approaches for understanding complex traits with relevance for human disease
Quantitative traits are often complex because of the contribution of many loci, with further
complexity added by environmental factors. In medical research, systems genetics is a …
complexity added by environmental factors. In medical research, systems genetics is a …
Genetics: implications for prevention and management of coronary artery disease
TL Assimes, R Roberts - Journal of the American College of cardiology, 2016 - jacc.org
An exciting new era has dawned for the prevention and management of coronary artery
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …
disease (CAD) utilizing genetic risk variants. The recent identification of over 60 …
The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis
S Xu, Y Xu, P Liu, S Zhang, H Liu, S Slavin… - European heart …, 2019 - academic.oup.com
Aims Recent genome-wide association studies (GWAS) have identified that the JCAD locus
is associated with risk of coronary artery disease (CAD) and myocardial infarction (MI) …
is associated with risk of coronary artery disease (CAD) and myocardial infarction (MI) …
Tissue-specific pathways and networks underlying sexual dimorphism in non-alcoholic fatty liver disease
Z Kurt, R Barrere-Cain, J LaGuardia… - Biology of sex …, 2018 - Springer
Background Non-alcoholic fatty liver disease (NAFLD) encompasses benign steatosis and
more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver …
more severe conditions such as non-alcoholic steatohepatitis (NASH), cirrhosis, and liver …