Navigating beyond associations: Opportunities to establish causal relationships between the gut microbiome and colorectal carcinogenesis
The gut microbiota has been recognized as an important determinant in the initiation and
progression of colorectal cancer (CRC), with recent studies shining light on the molecular …
progression of colorectal cancer (CRC), with recent studies shining light on the molecular …
Guideline for designing microbiome studies in neoplastic diseases
Oncobiosis has emerged as a key contributor to the development, and modulator of the
treatment efficacy of cancer. Hereby, we review the modalities through which the oncobiome …
treatment efficacy of cancer. Hereby, we review the modalities through which the oncobiome …
Current status and prospect of the DNA double-strand break repair pathway in colorectal cancer development and treatment
K Yang, L Zhu, C Liu, D Zhou, Z Zhu, N Xu… - Biochimica et Biophysica …, 2024 - Elsevier
Colorectal cancer (CRC) is one of the most common malignancies worldwide. Double-
strand break (DSB) is the most severe type of DNA damage. However, few reviews have …
strand break (DSB) is the most severe type of DNA damage. However, few reviews have …
Dysfunctional mucus structure in cystic fibrosis increases vulnerability to colibactin-mediated DNA adducts in the colon mucosa
A Mandarino Alves, C Lecchi, S Lopez, A Stornetta… - Gut …, 2024 - Taylor & Francis
Colibactin is a recently characterized pro-carcinogenic genotoxin produced by pks+
Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus …
Escherichia coli. We hypothesized that cystic fibrosis (CF)-associated dysfunctional mucus …
[HTML][HTML] Novel insights into tumorigenesis revealed by molecular analysis of Lynch syndrome cases with multiple colorectal tumors
A Olkinuora, S Mäki-Nevala, S Ukwattage… - Frontiers in …, 2024 - ncbi.nlm.nih.gov
Background Lynch syndrome (LS) is an autosomal dominant multi-organ cancer syndrome
with a high lifetime risk of cancer. The number of cumulative colorectal adenomas in LS …
with a high lifetime risk of cancer. The number of cumulative colorectal adenomas in LS …