Somatostatin in the central nervous system: Physiology and pathological modifications -
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Since its discovery over four decades ago, somatostatin (SOM) receives growing scientific
and clinical interest. Being localized in the nervous system in a subset of interneurons …

The localization and distribution of somatostatin (growth hormone release-inhibiting
hormone; somatotropin release-inhibiting factor) have been studied with the indirect …

Neurons in the monkey and rat cerebral cortex immunoreactive for somatostatin
tetradecapeptide (SRIF) and for neuropeptide Y (NPY) were examined in the light and …

A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons.
These complex inhibitory interconnections largely contribute to the tight modulation of …

The influence of sustained epileptic seizures evoked by intraperitoneal injection of kainic
acid on the gene expression of the neuropeptides somatostatin and neuropeptide Y and on …

The distribution of somatostatinlike immunoreactivity was studied in the hippocampal
formation, retrohippocampal region, and temporal cortex in the human brain. Tissues from …

Although neuropeptides have been demonstrated to be hippocampal neuromodulators in
laboratory animals, their role in human hippocampal physiology or pathophysiology remains …

Immunocytochemical and electrophysiological evidence suggests that somatostatin may be
a transmitter in the hippocampus. To characterize the ionic mechanisms underlying …

Superfusion onto hippocampal slices of low concentrations of the tetradecapeptide
somatostatin (SS), or an SS analogue having CNS activity, reversibly hyperpolarized …