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Signalling mechanisms and cellular functions of SUMO
Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …
number of modifying enzymes but regulates thousands of target proteins in a dynamic …
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion
The MYC proto-oncogenes encode a family of transcription factors that are among the most
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …
commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or …
The role of ubiquitination in tumorigenesis and targeted drug discovery
Ubiquitination, an important type of protein posttranslational modification (PTM), plays a
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
crucial role in controlling substrate degradation and subsequently mediates the “quantity” …
SUMO: from bench to bedside
Sentrin/small ubiquitin-like modifier (SUMO) is protein modification pathway that regulates
multiple biological processes, including cell division, DNA replication/repair, signal …
multiple biological processes, including cell division, DNA replication/repair, signal …
Target gene-independent functions of MYC oncoproteins
Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …
body of evidence indicates that MYC proteins are transcription factors, studying their function …
Synthetic lethal therapies for cancer: what's next after PARP inhibitors?
The genetic concept of synthetic lethality has now been validated clinically through the
demonstrated efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of …
demonstrated efficacy of poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of …
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
RNA-binding proteins (RBPs) are critical regulators of post-transcriptional gene expression,
and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate …
and aberrant RBP-RNA interactions can promote cancer progression. Here, we interrogate …
[HTML][HTML] The post-translational modification, SUMOylation, and cancer
ZJ Han, YH Feng, BH Gu, YM Li… - … journal of oncology, 2018 - spandidos-publications.com
SUMOylation is a reversible post-translational modification which has emerged as a crucial
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …
molecular regulatory mechanism, involved in the regulation of DNA damage repair, immune …
Discovery of TAK-981, a first-in-class inhibitor of SUMO-activating enzyme for the treatment of cancer
SP Langston, S Grossman, D England… - Journal of medicinal …, 2021 - ACS Publications
SUMOylation is a reversible post-translational modification that regulates protein function
through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of …
through covalent attachment of small ubiquitin-like modifier (SUMO) proteins. The process of …
Sumoylation on its 25th anniversary: mechanisms, pathology, and emerging concepts
Sumoylation is an essential post‐translational modification intimately involved in a diverse
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …
range of eukaryotic cellular mechanisms. Small ubiquitin‐like modifier (SUMO) protein …