Infectious diseases continue to claim many lives. Prevention of morbidity and mortality from
these diseases would benefit not just from new medicines and vaccines but also from a …

Type I interferons (IFNs) have diverse effects on innate and adaptive immune cells during
infection with viruses, bacteria, parasites and fungi, directly and/or indirectly through the …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Background Identification of blood biomarkers that prospectively predict progression of
Mycobacterium tuberculosis infection to tuberculosis disease might lead to interventions that …

Humans encounter mycobacterial species due to their ubiquity in different environmental
niches. In many individuals, pathogenic mycobacterial species may breach our first-line …

Type I interferons (IFNs) activate intracellular antimicrobial programmes and influence the
development of innate and adaptive immune responses. Canonical type I IFN signalling …

Type I interferons (IFNs) are critical mediators of antiviral defense, but their elicitation by
bacterial pathogens can be detrimental to hosts. Many intracellular bacterial pathogens …

Aging-associated cognitive decline is affected by factors produced inside and outside the
brain. By using multiorgan genome-wide analysis of aged mice, we found that the choroid …

Summary Mycobacterium tuberculosis (Mtb) causes 1.6 million deaths annually. Active
tuberculosis correlates with a neutrophil-driven type I interferon (IFN) signature, but the …

Type I interferons (IFNs) are pleiotropic cytokines well recognized for their role in the
induction of a potent antiviral gene program essential for host defense against viruses. They …