Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and
particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic …

Hepatic stellate cells (HSCs) comprise a minor cell population in the liver but serve
numerous critical functions in the normal liver and in response to injury. HSCs are primarily …

The concept of hepatocyte functional zonation is well established, with differences in
metabolism and xenobiotic processing determined by multiple factors including oxygen and …

Single-cell RNA sequencing (scRNA-seq) provides unique insights into the pathology and
cellular origin of disease. We introduce single-cell disease relevance score (scDRS), an …

Tissues within an organism and even cell types within a tissue can age with different
velocities. However, it is unclear whether cells of one type experience different aging …

Nonalcoholic fatty liver disease (NAFLD), a spectrum of metabolic liver disease associated
with obesity, ranges from relatively benign hepatic steatosis to nonalcoholic steatohepatitis …

Hepatocytes, the liver's predominant cells, perform numerous essential biological functions.
However, crucial events and regulators during hepatocyte maturation require in-depth …

Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary
human hepatocytes are the gold standard model for the assessment of drug efficacy, safety …

The mechanisms underlying liver fibrosis are multifaceted and remain elusive with no
approved antifibrotic treatments available. The adult zebrafish has been an underutilized …

Single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of cellular
heterogeneity and the dynamics of gene expression, bearing profound significance in stem …