Abstract Background and Objective Although comprehensive and widespread guidelines on
how to conduct systematic reviews of outcome measurement instruments (OMIs) exist, for …

Importance Complete information in a trial protocol regarding study outcomes is crucial for
obtaining regulatory approvals, ensuring standardized trial conduct, reducing research …

The use of real-world data (RWD) for generating real-world evidence (RWE) to complement
interventional clinical trial-based research is rapidly increasing. This evolving field is …

Background In patients with heart failure and reduced ejection fraction, sleep-disordered
breathing, comprising obstructive sleep apnoea (OSA) and central sleep apnoea (CSA), is …

GRN mutations cause progranulin haploinsufficiency, which eventually leads to
frontotemporal dementia (FTD-GRN). PR006 is an investigational gene therapy delivering …

Background Affective responses are increasingly recognized as potentially effective
intervention targets that may facilitate exercise and physical activity behavior change. While …

Randomised controlled trials commonly use surrogate endpoints to substitute for a target
outcome (outcome of direct interest and relevance to trial participants, clinicians, and other …

Importance The benefit of endovascular stroke therapy (EVT) in large vessel occlusion
(LVO) ischemic stroke is highly time dependent. Process improvements to accelerate in …

Background: There is a lack of randomized controlled trial (RCT) data comparing outcomes
of different catheter-based interventions for intermediate-risk pulmonary embolism (PE) …

Randomised controlled trials often use surrogate endpoints to substitute for a target outcome
(an outcome of direct interest and relevance to trial participants, clinicians, and other …