Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

An estimated 50% of depressed patients are inadequately treated by available interventions.
Even with an eventual recovery, many patients require a trial and error approach, as there …

Depression is a major health problem with a high prevalence and a heavy socioeconomic
burden in western societies. It is associated with atrophy and impaired functioning of cortico …

During the last decades, schizophrenia has been regarded as a developmental disorder.
The neurodevelopmental hypothesis proposes schizophrenia to be related to genetic and …

Introduction The heterogeneity of symptoms and complex etiology of depression pose a
significant challenge to the personalization of treatment. Meanwhile, the current application …

Gene-by-environment interactions (G× Es) can provide important biological insights into
psychiatric disorders and may consequently have direct clinical implications. In this review …

Background: The differential susceptibly hypothesis suggests that certain genetic variants
moderate the effects of both negative and positive environments on mental health and may …

Fatigue, which is one of the most commonly reported symptoms in cancer, can negatively
impact the functional status and the health-related quality of life of individuals. This paper …

Depression is a common psychological disease with high morbidity and mortality. Recently,
the involvement of synaptic plasticity in the pathogenesis of depression has shed light on the …

Objective This article provides an overview of research on the neurobiological correlates of
childhood adversity and a selective review of treatment implications. Method Findings from a …