Therapeutic targets in lung tissue remodelling and fibrosis
Structural changes involving tissue remodelling and fibrosis are major features of many
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
pulmonary diseases, including asthma, chronic obstructive pulmonary disease (COPD) and …
Microbiome effects on immunity, health and disease in the lung
Chronic respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
(COPD) and cystic fibrosis (CF), are among the leading causes of mortality and morbidity …
Role for NLRP3 inflammasome–mediated, IL-1β–dependent responses in severe, steroid-resistant asthma
RY Kim, JW Pinkerton, AT Essilfie… - American journal of …, 2017 - atsjournals.org
Rationale: Severe, steroid-resistant asthma is the major unmet need in asthma therapy.
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
Disease heterogeneity and poor understanding of pathogenic mechanisms hampers the …
[HTML][HTML] The central role of IL-33/IL-1RL1 pathway in asthma: from pathogenesis to intervention
AKS Jayalatha, L Hesse, ME Ketelaar… - Pharmacology & …, 2021 - Elsevier
Abstract Interleukin-33 (IL-33), a member of the IL-1 family, and its cognate receptor,
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
Interleukin-1 receptor like-1 (IL-1RL1 or ST2), are susceptibility genes for childhood asthma …
Commentary: IL-4 and IL-13 receptors and signaling
SM McCormick, NM Heller - Cytokine, 2015 - Elsevier
Abstract Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 …
[HTML][HTML] Immunoregulatory and anti-inflammatory properties of Crocus sativus (Saffron) and its main active constituents: A review
The medicinal uses of saffron, the dried stigmas of Crocus sativus L., have very long history
in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …
in food coloring agent, and flavoring agent as well as traditional medicine for the treatment of …
Inflammasomes in the lung
Innate immune responses act as first line defences upon exposure to potentially noxious
stimuli. The innate immune system has evolved numerous intracellular and extracellular …
stimuli. The innate immune system has evolved numerous intracellular and extracellular …
Blood eosinophil count is a useful biomarker to identify patients with severe eosinophilic asthma
LE Katz, GJ Gleich, BF Hartley, SW Yancey… - Annals of the …, 2014 - atsjournals.org
Rationale: Measurement of sputum or blood eosinophils may allow identification of a severe
eosinophilic asthma population responsive to mepolizumab. Objectives: The primary …
eosinophilic asthma population responsive to mepolizumab. Objectives: The primary …
Mechanisms and treatments for severe, steroid‐resistant allergic airway disease and asthma
Severe, steroid‐resistant asthma is clinically and economically important since affected
individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with …
individuals do not respond to mainstay corticosteroid treatments for asthma. Patients with …
Role of lung microbiome in innate immune response associated with chronic lung diseases
Respiratory diseases such as asthma, chronic obstructive pulmonary disease (COPD), lung
fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the …
fibrosis, and lung cancer, pose a huge socio-economic burden on society and are one of the …