Chronic pain is a debilitating condition that often occurs following peripheral tissue
inflammation and nerve injury. This pain, especially neuropathic pain, is a significant clinical …

Pain can be induced by tissue injuries, diseases and infections. The interactions between
the peripheral nervous system (PNS) and immune system are primary actions in pain …

Pannexins are large-pore forming channels responsible for ATP release under a variety of
physiological and pathological conditions. Although predicted to share similar membrane …

Nanoparticle-mediated drug delivery is especially useful for targets within endosomes
because of the endosomal transport mechanisms of many nanomedicines within cells. Here …

Activation of purinergic receptors in the spinal cord by extracellular ATP is essential for
neuropathic hypersensitivity after peripheral nerve injury (PNI). However, the cell type …

Pannexin 1 (Panx1) is a membrane channel implicated in numerous physiological and
pathophysiological processes via its ability to support release of ATP and other cellular …

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious and often persistent
adverse consequence of certain chemotherapeutic agents. It is a major dose-limiting factor …

Abstract Pannexin‐1 (Panx1) is a large pore membrane channel with unique conduction
properties ranging from non‐selective ion permeability to the extracellular release of …

Neuroinflammation is a major component of central nervous system (CNS) injuries and
neurological diseases, including Alzheimer's disease, multiple sclerosis, neuropathic pain …

The contribution of reactive gliosis to the pathological phenotype of Alzheimer's disease
(AD) opened the way for therapeutic strategies targeting glial cells instead of neurons. In …