The cellular and molecular mechanisms underpinning tissue repair and its failure to heal are
still poorly understood, and current therapies are limited. Poor wound healing after trauma …

A considerable understanding of the fundamental cellular and molecular mechanisms
underpinning healthy acute wound healing has been gleaned from studying various animal …

Neural tube closure has been studied for many decades, across a range of vertebrates, as a
paradigm of embryonic morphogenesis. Neurulation is of particular interest in view of the …

The ability of skin to act as a barrier is primarily determined by cells that maintain the
continuity and integrity of skin and restore it after injury. Cutaneous wound healing in adult …

Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are
frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of …

To provide a stable environmental barrier, the epidermis requires an integrated network of
cytoskeletal elements and cellular junctions. Nevertheless, the epidermis ranks among the …

Orofacial clefts (OFCs), which include non-syndromic cleft lip with or without cleft palate
(CL/P), are among the most common birth defects in humans, affecting approximately 1 in …

Wound healing is an essential biological process that comprises sequential steps aimed at
restoring the architecture and function of damaged cells and tissues. This process begins …

Upon injury, the skin must quickly regenerate to regain its barrier function. In mammals,
wound healing is rapid and scar free during embryogenesis, whereas in adults it involves …

The importance of wound healing to medicine and biology has long been evident, and
consequently, wound healing has been the subject of intense investigation for many years …