Myeloid cells are the most abundant immune components of the tumour microenvironment,
where they have a variety of functions, ranging from immunosuppressive to …

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to
infection. In sepsis, a complicated immune response is initiated, which varies over time with …

Peroxynitrite, a short-lived and reactive oxidant, emerges from the diffusion-controlled
reaction between the superoxide radical and nitric oxide. Evidence shows that peroxynitrite …

Tumour microenvironment is a complex ecosystem in which myeloid cells are the most
abundant immune elements. This cell compartment is composed by different cell types …

There are two types of abnormal hematopoiesis in solid tumor occurrence and treatment:
pathological hematopoiesis, and myelosuppression induced by radiotherapy and …

Chronic stress is a significant risk factor that contributes to the progression of colorectal
cancer (CRC) and has garnered considerable attention in recent research. It influences the …

Myeloid-derived suppressor cells (MDSCs) are a group of bone marrow derived
heterogeneous cells, which is known for their immunosuppressive functions especially in …

AdAPT-001 is an investigational therapy consisting of a replicative type 5 adenovirus armed
with a TGF-β receptor-immunoglobulin Fc fusion trap, designed to neutralize isoforms 1 and …

Granulocyte-macrophage colony stimulating factor (GM-CSF) is a pleiotropic cytokine, able
to promote both myelopoiesis and activation of immune cells. Particularly in the lung, GM …

Myeloid cells are increasingly being recognized as central players orchestrating or
suppressing antitumor immune responses. With the advent of high-resolution analytical …