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Goods and bads of the endocannabinoid system as a therapeutic target: lessons learned after 30 years
The cannabis derivative marijuana is the most widely used recreational drug in the Western
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
world and is consumed by an estimated 83 million individuals (∼ 3% of the world …
[HTML][HTML] Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities
Abstract N-acylethanolamines (NAEs), including N-palmitoylethanolamine (PEA), N-
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
oleoylethanolamine (OEA), N-arachidonoylethanolamine (AEA, anandamide), N …
Palmitic acid: physiological role, metabolism and nutritional implications
Palmitic acid (PA) has been for long time negatively depicted for its putative detrimental
health effects, shadowing its multiple crucial physiological activities. PA is the most common …
health effects, shadowing its multiple crucial physiological activities. PA is the most common …
Cannabis: a multifaceted plant with endless potentials
Cannabis sativa, also known as “hemp” or “weed,” is a versatile plant with various uses in
medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available …
medicine, agriculture, food, and cosmetics. This review attempts to evaluate the available …
Controlled activation of TRPV1 channels on microglia to boost their autophagy for clearance of alpha‐synuclein and enhance therapy of Parkinson's disease
J Yuan, H Liu, H Zhang, T Wang, Q Zheng… - Advanced …, 2022 - Wiley Online Library
Parkinson's disease (PD) is characterized with accumulation of Lewy bodies with a major
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …
component of fibrillar alpha‐synuclein (α‐syn). Herein, boosting PD therapeutic efficacy by …
The pharmacology of palmitoylethanolamide and first data on the therapeutic efficacy of some of its new formulations
S Petrosino, V Di Marzo - British journal of pharmacology, 2017 - Wiley Online Library
Palmitoylethanolamide (PEA) has emerged as a potential nutraceutical, because this
compound is naturally produced in many plant and animal food sources, as well as in cells …
compound is naturally produced in many plant and animal food sources, as well as in cells …
Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy
Nothing is known about the potential implication of gut microbiota in skeletal muscle
disorders. Here, we provide evidence that fecal microbiota composition along with …
disorders. Here, we provide evidence that fecal microbiota composition along with …
Cannabidiol and other non-psychoactive cannabinoids for prevention and treatment of gastrointestinal disorders: useful nutraceuticals?
Cannabis sativa is an aromatic annual flowering plant with several botanical varieties, used
for different purposes, like the production of fibers, the production of oil from the seeds, and …
for different purposes, like the production of fibers, the production of oil from the seeds, and …
Targeting the endocannabinoid system: future therapeutic strategies
O Aizpurua-Olaizola, I Elezgarai, I Rico-Barrio… - Drug discovery today, 2017 - Elsevier
Highlights•Increased emphasis in recent years on drugs targeting the endocannabinoid
system.•Recent discoveries about the role of the endocannabinoid system are …
system.•Recent discoveries about the role of the endocannabinoid system are …
[HTML][HTML] TRPV1: structure, endogenous agonists, and mechanisms
M Benítez-Angeles, SL Morales-Lázaro… - International journal of …, 2020 - mdpi.com
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with
functions widely linked to the generation of pain. Several agonists of exogenous and …
functions widely linked to the generation of pain. Several agonists of exogenous and …