The tumor microenvironment is a complex ecology of cells that evolves with and provides
support to tumor cells during the transition to malignancy. Among the innate and adaptive …

How neoplastic cells respond to therapy is not solely dependent on the complexity of the
genomic aberrations they harbor but is also regulated by numerous dynamic properties of …

Chimeric antigen receptor (CAR) T cell therapy has shown promise in hematologic
malignancies, but its application to solid tumors has been challenging,,–. Given the unique …

Deleterious inflammation is a primary feature of breast cancer. Accumulating evidence
demonstrates that macrophages, the most abundant leukocyte population in mammary …

The role of tumor-associated macrophages (TAMs) in cancer is often correlated with poor
prognosis, even though this statement should be interpreted with care, as the effects of …

Tumor-associated macrophages (TAMs), representing most of the leukocyte population in
solid tumors, demonstrate great phenotypic heterogeneity and diverse functional capabilities …

Colony-stimulating factor 1 (CSF1) is a key regulator of monocyte/macrophage
differentiation that sustains the protumorigenic functions of tumor-associated macrophages …

Macrophages are a heterogeneous group of cells that are capable of carrying out distinct
functions in different tissues, as well as in different locations within a given tissue. Some of …

Evidence has emerged for macrophages in the perivascular niche of tumors regulating
important processes like angiogenesis, various steps in the metastatic cascade, the …

Our current understanding of human tumor-resident myeloid cells is, for the most part, based
on a large body of work in murine models or studies enumerating myeloid cells in patient …