The quest for alternative drugs to the well-known cisplatin and its derivatives, which are still
used in more than 50% of the treatment regimes for patients suffering from cancer, is highly …

The evolution of resistance to traditional platinum-based anticancer drugs has compelled
researchers to investigate the cytostatic properties of alternative transition metal-based …

Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …

The small molecule anticancer agent cisplatin and its Pt (II) analogs carboplatin and
oxaliplatin are widely used to treat a variety of tumorigenic diseases. Despite their structural …

Peptides are important biological molecular entities in biomedical research. They can be
prepared in a large variety of shapes, with a host of chemical functions, and tailored for …

Despite significant improvements in the treatment of cancerous tumors in the last decades,
cancer remains one of the deadliest diseases worldwide. To overcome the shortcomings of …

Gold (I) complexes with a 1, 3-diethylbenzimidazol-2-ylidene N-heterocyclic carbene (NHC)
ligand of the type NHC-Au-L (L=-Cl,-NHC, or-PPh3) were comparatively evaluated as …

Metal complexes are increasingly being used to inhibit enzymes. The reasons for this
increased interest arise from the special features that metal complexes offer, eg the facile …

Metallodrugs have a central role in the treatment and diagnosis of diseases. To overcome
potential toxicity and equip metal-based anticancer agents with biological activity, the choice …

Organometallic compounds are renowned for their remarkable applications in the field of
catalysis, but much less is known about their potential in chemical biology. Indeed, such …