Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

The blood–brain barrier (BBB) protects the central nervous system (CNS) from unregulated
exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain …

The advent of neuroimaging has increased our understanding of brain function. While most
brain-wide functional imaging modalities exploit neurovascular coupling to map brain …

Pericytes are multi-functional cells embedded within the walls of capillaries throughout the
body, including the brain. Pericytes were first identified in the 1870s, but little attention was …

Pericytes are unique, multi-functional mural cells localized at the abluminal side of the
perivascular space in microvessels. Originally discovered in 19th century, pericytes had …

Deterioration of brain capillary flow and architecture is a hallmark of aging and dementia. It
remains unclear how loss of brain pericytes in these conditions contributes to capillary …

Vascular dysfunction is frequently observed in disorders associated with cognitive
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …

Mesenchymal stem cell (MSC) transplantation is a promising treatment strategy for spinal
cord injury, but immunological rejection and possible tumor formation limit its application …

The brain is endowed with highly specialized vasculature that is both structurally and
functionally unique compared to vasculature supplying peripheral organs. The blood–brain …

The dense network of capillaries composed of capillary endothelial cells (cECs) and
pericytes lies in close proximity to all neurons, ideally positioning it to sense neuron-and …