Malaria is a serious parasitic disease in the develo** world, causing high morbidity and
mortality. The pathogenesis of malaria is complex, and the clinical presentation of disease …

Background Haemoglobinopathies can reduce the risk of malaria syndromes. We aimed to
quantify the relation between different haemoglobin mutations and malaria protection to …

Malaria has been a major selective force on the human population, and several erythrocyte
polymorphisms have evolved that confer resistance to severe malaria. Plasmodium …

In the century since the discovery of the ABO blood groups, numerous associations between
ABO groups and disease have been noted. However, the selection pressures defining the …

Cystic fibrosis (CF) is an autosomal recessive genetic disorder caused by mutations in
CFTR, the cystic fibrosis transmembrane conductance regulator gene. People with CF …

Endemic malaria, which claimed 229 million new cases and 409,000 deaths in 2019 mainly
in Africa, was eradicated from Europe by the mid-20th century. Historical descriptions of …

Background Malaria resistance by the sickle cell trait (genotype HbAS) has served as the
prime example of genetic selection for over half a century. Nevertheless, the mechanism of …

Hundreds of genes reside in structurally complex, poorly understood regions of the human
genome,,. One such region contains the three amylase genes (AMY2B, AMY2A and AMY1) …

There is growing epidemiological and molecular evidence that ABO blood group affects host
susceptibility to severe Plasmodium falciparum infection. The high frequency of common …

The malaria parasite Plasmodium falciparum utilizes molecules present on the surface of
uninfected red blood cells (RBC) for rosette formation, and a dependency on ABO antigens …