Over the past few decades, a significant number of anticancer drugs have been developed,
both natural and synthetic. Thiazole, a 5-membered distinctive heterocyclic motif with …

Sulfur‐containing heterocyclic derivatives have been disclosed for binding with a wide
range of cancer‐specific protein targets. Various interesting derivatives of sulfur‐containing …

In search for new anticancer candidates, a new series of enamide fluorinated‐Schiff base
derivatives were synthesized and confirmed by spectroscopic techniques as well as …

A novel series of pyrimidine-5-carbonitrile derivatives was designed, synthesized, then
evaluated for their cytotoxic activity as novel anti-cancer with dual EGFRWT/COX-2 …

The combretastatins (cis-stilbenoid molecules) have received significant interest because of
their simple chemical structures, excellent antiproliferative activity, and novel anti-tubulin …

Due to the important role of protein kinases in protein phosphorylation within vital cellular
processes, their abnormal function, especially in cancer situations, has underscored their …

New thiazole, thiazolopyrimidine, and thiazolotriazine derivatives 3–12 and 14a–f were
synthesized. The newly synthesized analogs were tested for in vitro antitumor activity …

Novel thiazole analogs 3a, 3b, 4, 5, 6a–g, 8a, 8b, 9a–c, 10a–d and 11 were designed and
synthesized as molecular mimetics of sunitinib. In vitro antitumor activity of the obtained …

Pyroptosis, as a lytic-inflammatory type of programmed cell death, has garnered
considerable attention due to its role in cancer chemotherapy and many inflammatory …

Abstract Some novel imidazo [2, 1-b] thiazole-matrine derivatives have been obtained by
utilizing a scaffold splicing strategy based on a lead compound, matrine, which has good …