Targeting different pathways using novel combination therapy in triple negative breast cancer

MA Mir, H Qayoom, U Mehraj, S Nisar… - Current cancer drug …, 2020 - ingentaconnect.com
Triple negative breast cancer (TNBC) is one of the most aggressive subtypes of breast
cancer accounting for 15-20% of cases and is defined by the lack of hormonal receptors viz …

Diabetic neuropathy: review on molecular mechanisms

MM Sanaye, SA Kavishwar - Current Molecular Medicine, 2023 - ingentaconnect.com
Diabetic mellitus is a worldwide endocrine and metabolic disorder with insulin insensitivity
or deficiency or both whose prevalence could rise up to 592 million by 2035. Consistent …

Girk3 deletion increases osteoblast maturation and bone mass accrual in adult male mice

SR Weaver, HM Torres, KM Arnold, EL Zars… - JBMR plus, 2024 - academic.oup.com
Osteoporosis and other metabolic bone diseases are prevalent in the aging population.
While bone has the capacity to regenerate throughout life, bone formation rates decline with …

Possible role of Wnt signaling pathway in diabetic retinopathy

S Sharma, T Behl, A Sehgal, S Singh… - Current Drug …, 2022 - benthamdirect.com
The core of impaired vision in working people suffering from insulin-dependent and
noninsulin-dependent diabetes mellitus is diabetic retinopathy (DR). The Wnt Protein …

Impaired transport activity of human organic anion transporters (OATs) and organic anion transporting polypeptides (OATPs) by wnt inhibitors

Y Ali, T Shams, Z Cheng, Y Li, CS Chun, W Shu… - Journal of …, 2021 - Elsevier
The Wnt/β-catenin signaling pathway is dysregulated in diseases and Wnt inhibitors like PRI-
724 are in clinical development. This study evaluated the regulatory actions of PRI-724 and …

[PDF][PDF] Identificación preliminar de variantes patógenas en una familia raizal afrocolombiana con factores de riesgo para glaucoma

H Castillo-Plata, N Rivera-Franco, C Valencia-Peña… - Colombia …, 2022 - redalyc.org
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Relationship between villous atrophy and Wnt pathway gene expressions in pediatric celiac patients

M Caliskan, G Dogan… - Revista da Associação …, 2023 - SciELO Brasil
SUMMARY OBJECTIVE: Celiac disease is an autoimmune disease characterized by an
abnormal immune response occurring in the small intestine linked to consumption of food …

[PDF][PDF] Application of Systems Biology Methods in Understanding the Molecular Mechanism of Signalling Pathways in the Eukaryotic System

AR SJ, M Paramesha - Frontiers, 2020 - researchgate.net
A signalling pathway is a cascade of reactions carried out together by a group of molecules
in a system to bring out the metabolic functions starting with cell division to cell death. When …