Lipoprotein lipase: from gene to obesity

H Wang, RH Eckel - American Journal of Physiology …, 2009 - journals.physiology.org
Lipoprotein lipase (LPL) is a multifunctional enzyme produced by many tissues, including
adipose tissue, cardiac and skeletal muscle, islets, and macrophages. LPL is the rate …

Biochemistry and pathophysiology of intravascular and intracellular lipolysis

SG Young, R Zechner - Genes & development, 2013 - genesdev.cshlp.org
All organisms use fatty acids (FAs) for energy substrates and as precursors for membrane
and signaling lipids. The most efficient way to transport and store FAs is in the form of …

ApoC-III inhibits clearance of triglyceride-rich lipoproteins through LDL family receptors

PLSM Gordts, R Nock, NH Son, B Ramms, I Lew… - The Journal of clinical …, 2016 - jci.org
Hypertriglyceridemia is an independent risk factor for cardiovascular disease, and plasma
triglycerides (TGs) correlate strongly with plasma apolipoprotein C-III (ApoC-III) levels …

Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons

AP Beigneux, BSJ Davies, P Gin, MM Weinstein… - Cell metabolism, 2007 - cell.com
The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LpL) along the
luminal surface of the capillaries. However, the endothelial cell molecule that facilitates …

The role of lipid sensing nuclear receptors (PPARs and LXR) and metabolic lipases in obesity, diabetes and NAFLD

ED Dixon, AD Nardo, T Claudel, M Trauner - Genes, 2021 - mdpi.com
Obesity and type 2 diabetes mellitus (T2DM) are metabolic disorders characterized by
metabolic inflexibility with multiple pathological organ manifestations, including non …

Regulation of lipoprotein lipase by the oxysterol receptors, LXRα and LXRβ

Y Zhang, JJ Repa, K Gauthier… - Journal of Biological …, 2001 - jbc.org
Lipoprotein lipase (LPL) is a key enzyme for lipoprotein metabolism and is responsible for
hydrolysis of triglycerides in circulating lipoproteins, releasing free fatty acids to peripheral …

Lipoprotein lipase: the regulation of tissue specific expression and its role in lipid and energy metabolism

K Preiss-Landl, R Zimmermann… - Current opinion in …, 2002 - journals.lww.com
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[HTML][HTML] Effects of diets with different energy and bile acids levels on growth performance and lipid metabolism in broilers

XK Ge, AA Wang, ZX Ying, LG Zhang, WP Su, K Cheng… - Poultry science, 2019 - Elsevier
This experiment was conducted to evaluate the effects of bile acids (BAs) on the growth
performance and lipid metabolism of broilers fed with different energy level diets. 480 one …

Lipoprotein lipase S447X: a naturally occurring gain-of-function mutation

J Rip, MC Nierman, CJ Ross, JW Jukema… - … , and vascular biology, 2006 - ahajournals.org
Lipoprotein lipase (LPL) hydrolyzes triglycerides in the circulation and promotes the hepatic
uptake of remnant lipoproteins. Since the gene was cloned in 1989, more than 100 LPL …

High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease

L Rohrer, M Hersberger… - Current opinion in …, 2004 - journals.lww.com
The protective properties of HDL in cytokine production, lipid oxidation, cholesterol efflux
and reverse cholesterol transport make HDL a protective agent in inflammation-induced …