The term B-factor, sometimes called the Debye–Waller factor, temperature factor, or atomic
displacement parameter, is used in protein crystallography to describe the attenuation of X …

Recent developments in computational chemistry and biology have come together in the
“inside‐out” approach to enzyme engineering. Proteins have been designed to catalyze …

The area of biocatalysis itself is in rapid development, fueled by both an enhanced
repertoire of protein engineering tools and an increasing list of solved problems …

Asymmetric catalysis plays a key role in modern synthetic organic chemistry, with synthetic
catalysts and enzymes being the two available options. During the latter part of the last …

During the recent past years, tremendous efforts have been made to establish
enantioselective routes for the preparation of enantiomerically pure compounds due to their …

Determining the principal energy-transfer pathways responsible for allosteric communication
in biomolecules remains challenging, partially due to the intrinsic complexity of the systems …

Enzyme stability is an important issue for protein engineers. Understanding how rigidity in
the active site affects protein kinetic stability will provide new insight into enzyme …

There is great interest in increasing proteins' stability to enhance their utility as biocatalysts,
therapeutics, diagnostics and nanomaterials. Directed evolution is a powerful, but …

Directed evolution is widely used to improve enzymes, particularly for industrial biocatalytic
processes. Molecular biology advances present many new strategies for directed evolution …

Additive or non‐additive, that is the question: The increasing awareness of non‐additive
cooperative mutational effects in protein engineering is currently providing new theoretical …