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Neutrophils in cancer: heterogeneous and multifaceted
Neutrophils are the most abundant myeloid cells in human blood and are emerging as
important regulators of cancer. However, their functional importance has often been …
important regulators of cancer. However, their functional importance has often been …
Contributions of eosinophils to human health and disease
AD Klion, SJ Ackerman… - Annual Review of …, 2020 - annualreviews.org
The human eosinophil has long been thought to favorably influence innate mucosal
immunity but at times has also been incriminated in disease pathophysiology. Research into …
immunity but at times has also been incriminated in disease pathophysiology. Research into …
Selective advantage of mutant stem cells in human clonal hematopoiesis is associated with attenuated response to inflammation and aging
Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSCs) acquire mutations,
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
most frequently in the DNMT3A and TET2 genes, conferring a competitive advantage …
[HTML][HTML] Single-cell proteo-genomic reference maps of the hematopoietic system enable the purification and massive profiling of precisely defined cell states
Single-cell genomics technology has transformed our understanding of complex cellular
systems. However, excessive cost and a lack of strategies for the purification of newly …
systems. However, excessive cost and a lack of strategies for the purification of newly …
[HTML][HTML] Map** transcriptomic vector fields of single cells
Summary Single-cell (sc) RNA-seq, together with RNA velocity and metabolic labeling,
reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
reveals cellular states and transitions at unprecedented resolution. Fully exploiting these …
The ingenious mast cell: Contemporary insights into mast cell behavior and function
Mast cells are (in) famous for their role in allergic diseases, but the physiological and
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are …
Single-cell proteomics and transcriptomics capture eosinophil development and identify the role of IL-5 in their lineage transit amplification
J Jorssen, G Van Hulst, K Mollers, J Pujol, G Petrellis… - Immunity, 2024 - cell.com
The activities, ontogeny, and mechanisms of lineage expansion of eosinophils are less well
resolved than those of other immune cells, despite the use of biological therapies targeting …
resolved than those of other immune cells, despite the use of biological therapies targeting …
Defining mast cell differentiation and heterogeneity through single-cell transcriptomics analysis
Mast cells (MCs) are widely recognized as central effector cells during type 2 inflammatory
reactions and thought to also play a role in innate immune responses, wound healing, and …
reactions and thought to also play a role in innate immune responses, wound healing, and …
CD66b−CD64dimCD115− cells in the human bone marrow represent neutrophil-committed progenitors
F Calzetti, G Finotti, N Tamassia… - Nature …, 2022 - nature.com
Here we report the identification of human CD66b− CD64dimCD115− neutrophil-committed
progenitor cells (NCPs) within the SSCloCD45dimCD34+ and CD34dim/− subsets in the …
progenitor cells (NCPs) within the SSCloCD45dimCD34+ and CD34dim/− subsets in the …
Mechanisms of progression of myeloid preleukemia to transformed myeloid leukemia in children with Down syndrome
M Labuhn, K Perkins, S Matzk, L Varghese, C Garnett… - Cancer cell, 2019 - cell.com
Myeloid leukemia in Down syndrome (ML-DS) clonally evolves from transient abnormal
myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of …
myelopoiesis (TAM), a preleukemic condition in DS newborns. To define mechanisms of …