Protein synthesis by the ribosome can fail for numerous reasons including faulty mRNA,
insufficient availability of charged tRNAs and genetic errors. All organisms have evolved …

Most mitochondrial proteins are synthesized as precursor proteins on cytosofic polysomes
and are subsequently imported into mitochondria. Many precursors carry amino-terminal …

New textbooks at all levels of chemistry appear with great regularity. Some fields like basic
biochemistry, organic reaction mechanisms, and chemical thermody namics are well …

MEMBERS of a family of murine octamer-binding proteins inter-act specifically with the
octamer motif, a transcription regulatory element found in the promoter and enhancer …

Depletion of a subset of 7OK stress proteins in yeast mutants shows that they are involved in
the post-translational import of precursor polypeptides into both mitochondria and the lumen …

The organization of the visual cortex has been considered to be highly stable in adult
mammals. However, 5° to 10° lesions of the retina in the contralateral eye markedly altered …

A yeast cytosol is shown to contain two distinct activities that stimulate protein translocation
across microsomal membranes. One activity was purified. It consists of two constitutively …

Quality control of defective mRNAs relies on their translation to detect the lesion. Aberrant
proteins are therefore an obligate byproduct of mRNA surveillance and must be degraded to …

The cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride ion channel
constructed from two membrane‐spanning domains (MSDs), two nucleotide‐binding …

Nonstop decay is the mechanism of identifying and disposing aberrant transcripts that lack
in‐frame stop codons. It is hypothesized that these transcripts are identified during …