Detection and analysis of chiral molecules as disease biomarkers

Y Liu, Z Wu, DW Armstrong, H Wolosker… - Nature Reviews …, 2023 - nature.com
The chirality of small metabolic molecules is important in controlling physiological processes
and indicating the health status of humans. Abnormal enantiomeric ratios of chiral molecules …

Enhancement of the capabilities of liquid chromatography–mass spectrometry with derivatization: general principles and applications

F Xu, L Zou, Y Liu, Z Zhang… - Mass spectrometry …, 2011 - Wiley Online Library
The integration of liquid chromatography–mass spectrometry (LC–MS) with derivatization is
a relatively new and unique strategy that could add value and could enhance the …

Resistance to host antimicrobial peptides mediates resilience of gut commensals during infection and aging in Drosophila

A Arias-Rojas, D Frahm, R Hurwitz… - Proceedings of the …, 2023 - National Acad Sciences
Resilience to short-term perturbations, like inflammation, is a fundamental feature of
microbiota, yet the underlying mechanisms of microbiota resilience are incompletely …

A sensitive and simple ultra-high-performance-liquid chromatography–tandem mass spectrometry based method for the quantification of d-amino acids in body fluids

WF Visser, NM Verhoeven-Duif, R Ophoff… - … of Chromatography A, 2011 - Elsevier
d-Amino acids are increasingly being recognized as important signaling molecules in
mammals, including humans. d-Serine and d-aspartate are believed to act as signaling …

Use of Marfey's reagent and analogs for chiral amino acid analysis: assessment and applications to natural products and biological systems

R Bhushan, H Brückner - Journal of Chromatography B, 2011 - Elsevier
The present paper describes an updated knowledge and status on Marfey's reagent (MR), 1-
fluoro-2, 4-dinitrophenyl-5-l-alanine amide (FDNP-l-Ala-NH2). The reagent is used for pre …

Application of TLC, HPLC and GC methods to the study of amino acid and peptide enantiomers: a review

M Dołowy, A Pyka - Biomedical Chromatography, 2014 - Wiley Online Library
Amino acids are very important organic compounds in nature. The biological activity of
amino acids depends mainly on their stereoisomeric configuration (d‐or l‐). Thus, the …

Dopamine-modified TiO 2 monolith-assisted LDI MS imaging for simultaneous localization of small metabolites and lipids in mouse brain tissue with enhanced …

Q Wu, JL Chu, SS Rubakhin, MU Gillette… - Chemical …, 2017 - pubs.rsc.org
Localization of metabolites using multiplexed mass spectrometry imaging (MSI) provides
important chemical information for biological research. In contrast to matrix-assisted laser …

Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny

ME Wimmer, LA Briand, B Fant, LA Guercio… - Molecular …, 2017 - nature.com
Paternal environmental perturbations including exposure to drugs of abuse can produce
profound effects on the physiology and behavior of offspring via epigenetic modifications …

Serine lipids of Porphyromonas gingivalis are human and mouse Toll-like receptor 2 ligands

RB Clark, JL Cervantes, MW Maciejewski… - Infection and …, 2013 - Am Soc Microbiol
The total cellular lipids of Porphyromas gingivalis, a known periodontal pathogen, were
previously shown to promote dendritic cell activation and inhibition of osteoblasts through …

Cerebrospinal fluid amino acids glycine, serine, and threonine in nonketotic hyperglycinemia

MA Swanson, K Miller, SP Young… - Journal of Inherited …, 2022 - Wiley Online Library
Nonketotic hyperglycinemia (NKH) is caused by deficient glycine cleavage enzyme activity
and characterized by elevated brain glycine. Metabolism of glycine is connected …