A brief overview of global trends in MSC-based cell therapy
Human mesenchymal stem cells (MSCs), also known as mesenchymal stromal cells or
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …
medicinal signaling cells, are important adult stem cells for regenerative medicine, largely …
Gene therapy approach with an emphasis on growth factors: theoretical and clinical outcomes in neurodegenerative diseases
The etiology of many neurological diseases affecting the central nervous system (CNS) is
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
unknown and still needs more effective and specific therapeutic approaches. Gene therapy …
ApoE-isoform-dependent SARS-CoV-2 neurotropism and cellular response
ApoE4, a strong genetic risk factor for Alzheimer disease, has been associated with
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
increased risk for severe COVID-19. However, it is unclear whether ApoE4 alters COVID-19 …
Develo** hypoimmunogenic human iPSC‐derived oligodendrocyte progenitor cells as an off‐the‐shelf cell therapy for myelin disorders
Demyelinating disorders are among the most common and debilitating diseases in
neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of …
neurology. Canavan disease (CD) is a lethal demyelinating disease caused by mutation of …
Develo** enhanced immunotherapy using NKG2A knockout human pluripotent stem cell-derived NK cells
Cancer immunotherapy is gaining increasing attention. However, immune checkpoints are
exploited by cancer cells to evade anti-tumor immunotherapy. Here, we knocked out …
exploited by cancer cells to evade anti-tumor immunotherapy. Here, we knocked out …
Dual-function AAV gene therapy reverses late-stage Canavan disease pathology in mice
The leukodystrophy Canavan disease is a fatal white matter disorder caused by loss-of-
function mutations of the aspartoacylase-encoding ASPA gene. There are no effective …
function mutations of the aspartoacylase-encoding ASPA gene. There are no effective …
Develo** a human iPSC-derived three-dimensional myelin spheroid platform for modeling myelin diseases
Myelin defects cause a collection of myelin disorders in the brain. The lack of human models
has limited us from better understanding pathological mechanisms of myelin diseases …
has limited us from better understanding pathological mechanisms of myelin diseases …
Virus-based biological systems as next-generation carriers for the therapy of central nervous system diseases
I Nowak, M Madej, J Secemska, R Sarna… - Pharmaceutics, 2023 - mdpi.com
Central nervous system (CNS) diseases are currently a major challenge in medicine. One
reason is the presence of the blood–brain barrier, which is a significant limitation for …
reason is the presence of the blood–brain barrier, which is a significant limitation for …
The Role of Induced Pluripotent Stem Cells in the Treatment of Stroke
Stroke is a neurological disorder with high disability and mortality rates. Almost 80% of
stroke cases are ischemic stroke, and the remaining are hemorrhagic stroke. The only …
stroke cases are ischemic stroke, and the remaining are hemorrhagic stroke. The only …
Canavan disease as a model for gene therapy-mediated myelin repair
A Lotun, DJ Gessler, G Gao - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
In recent years, the scientific and therapeutic fields for rare, genetic central nervous system
(CNS) diseases such as leukodystrophies, or white matter disorders, have expanded …
(CNS) diseases such as leukodystrophies, or white matter disorders, have expanded …